PMID: 6405580Mar 1, 1983Paper

Autoradiography of manganese: accumulation and retention in the pancreas

Acta Pharmacologica Et Toxicologica
A LydénN G Lindquist

Abstract

By means of whole-body autoradiography, the general distribution of 54MnCl2 was studied in mice and a Marmoset monkey. High accumulation and retention were observed in the pancreas in both species. Gamma counting experiments in mice after a single intravenous injection of 54MnCl2 showed that the level in the pancreas exceeded that of the liver at all survival times (20 min. - 30 days). Also in the monkey, the concentration in the pancreas exceeded that of the liver, and the pancreas had the highest tissue/liver ratio of the organs measured at 24 hours after injection. The high uptake and long retention in the pancreas suggest that manganese is of importance for the pancreatic function but also that the pancreas may be a target organ for manganese toxicity. Positron tomography, using 11C-labelled amino acids, has been found to be a promising diagnostic technique for the study of pancreatic disease. Positron emitting manganese isotopes may be worth further studies as possible agents for pancreatic imaging.

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Citations

Jan 1, 1986·Critical Reviews in Microbiology·F Archibald
Jan 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B GallezH M Swartz
Feb 6, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Galit SaarAlan P Koretsky
Jan 1, 1985·Critical Reviews in Toxicology·P BénardA G Rico
Jan 23, 2019·Frontiers in Neural Circuits·Galit Saar, Alan P Koretsky
Sep 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·K P AicherC D Claussen
Mar 22, 2003·European Journal of Radiology·Hanns-Joachim WeinmannHeribert Schmitt-Willich
Sep 1, 1989·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·A NonakaK Makino

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