Autoreactive CD19+CD20- Plasma Cells Contribute to Disease Severity of Experimental Autoimmune Encephalomyelitis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Ding ChenNancy L Monson

Abstract

The contribution of autoantibody-producing plasma cells in multiple sclerosis (MS) remains unclear. Anti-CD20 B cell depletion effectively reduces disease activity in MS patients, but it has a minimal effect on circulating autoantibodies and oligoclonal bands in the cerebrospinal fluid. Recently we reported that MEDI551, an anti-CD19 mAb, therapeutically ameliorates experimental autoimmune encephalomyelitis (EAE), the mouse model of MS. MEDI551 potently inhibits pathogenic adaptive immune responses, including depleting autoantibody-producing plasma cells. In the present study, we demonstrated that CD19 mAb treatment ameliorates EAE more effectively than does CD20 mAb. Myelin oligodendrocyte glycoprotein-specific Abs and short-lived and long-lived autoantibody-secreting cells were nearly undetectable in the CD19 mAb-treated mice, but they remained detectable in the CD20 mAb-treated mice. Interestingly, residual disease severity in the CD20 mAb-treated animals positively correlated with the frequency of treatment-resistant plasma cells in the bone marrow. Of note, treatment-resistant plasma cells contained a substantial proportion of CD19(+)CD20(-) plasma cells, which would have otherwise been targeted by CD19 mAb. These data sug...Continue Reading

References

Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristina BecanovicTomas Olsson
Mar 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Chris H PolmanStephen C Reingold
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Norihito YazawaThomas F Tedder
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·David J DiLilloThomas F Tedder
Feb 15, 2008·The New England Journal of Medicine·Stephen L HauserUNKNOWN HERMES Trial Group
Jun 28, 2008·Journal of Neuroimmunology·M V JonesP A Calabresi
Jul 8, 2010·The Journal of Pharmacology and Experimental Therapeutics·Ronald HerbstAnthony J Coyle
Jan 1, 2009·F1000 Biology Reports·Paolo Fiorina, Mohamed H Sayegh
Dec 22, 2010·Annals of the Rheumatic Diseases·Karen FröhlichFrank Moosig
Jan 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·David J DiLilloThomas F Tedder
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Nov 19, 2011·Multiple Sclerosis International·Sara Ireland, Nancy Monson
Aug 31, 2012·Methods in Molecular Biology·Praveen Rao, Benjamin M Segal
Oct 10, 2012·Nature Reviews. Neurology·Markus KrumbholzEdgar Meinl
Dec 18, 2012·The Journal of Clinical Investigation·Matthieu MahévasClaude-Agnès Reynaud
Apr 18, 2013·Human Reproduction·Maziar RahmaniAngela Brooks-Wilson
Jul 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pankaj BansalE Sally Ward
Oct 12, 2013·Annals of the Rheumatic Diseases·Qingyu ChengFalk Hiepe
Feb 28, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wensheng WangJennifer H Anolik
May 1, 2013·International Journal of Clinical Pediatric Dentistry·Rakesh Namdeoraoji BahadureGautam P Badole

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Citations

Feb 17, 2017·Molecular Immunology·Sandra GallagherYue Wang
Sep 21, 2017·International Journal of Molecular Sciences·Katja SchmitzIrmgard Tegeder
Nov 28, 2017·Acta Neuropathologica Communications·Karolin PollokAnja Erika Hauser
Jul 8, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Georgina GaliciaJennifer L Gommerman
Jan 31, 2017·Journal of Clinical Medicine·Jason S Ellis, Helen Braley-Mullen
Mar 30, 2018·Therapeutic Advances in Neurological Disorders·Thomas G ForsthuberOlaf Stüve
Oct 24, 2018·International Journal of Molecular Sciences·James L Quinn, Robert C Axtell
Nov 18, 2018·Nature Reviews. Nephrology·Kristine OleinikaAlan D Salama
Apr 11, 2019·Nature Reviews. Rheumatology·Samuel J S RubinWilliam H Robinson
Apr 16, 2020·Frontiers in Neurology·Marion T TurnbullWilliam D Freeman
Mar 1, 2017·Transgenic Research·W IversonY Wang
Nov 12, 2018·Auto- Immunity Highlights·Georgios K VasileiadisGeorgios M Hadjigeorgiou
Oct 10, 2020·Expert Opinion on Therapeutic Targets·Lauren M Mathias, William Stohl
Mar 22, 2020·Epilepsy & Behavior : E&B·Niels HansenChristian E Elger

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