PMID: 2491630Jan 1, 1989Paper

Autoreactive cytotoxic T lymphocytes in pemphigus and pemphigoid

Autoimmunity
Sergei A GrandoO F Senyuk

Abstract

In order to know whether effector cells are capable of recognizing the epidermal targets in pemphigus vulgaris (PV) and bullous pemphigoid (BP), non-adherent cells (NAC) of peripheral blood from 27 primary PV, 19 BP patients and 12 healthy volunteers were used in cytotoxic tests. Autologous, allogenic and murine epidermal keratinocytes as well as autologous and allogenic fibroblasts were employed as targets. Total esterase activity of serine proteinases was measured in supernatants of samples and the results obtained were compared with the data received in 51Cr-release assay. These two techniques yielded similar results. The effector cells of PV and BP patients were found to lyse the epidermal target cells without presensitization in vitro. Epidermal cells from involved and uninvolved skin of PV patients, as well as from perilesional skin of BP patients, were highly sensitive to cytotoxic effect on the part of effector cells. The NAC activity in BP was higher than in PV. On the one hand, the obtained data suggest that PV and BP patients develop autoreactive cytotoxic T lymphocytes, sensitized to pemphigus and pemphigoid antigens, respectively, and on the other hand that epidermocytes in pemphigus and pemphigoid patients turned ...Continue Reading

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Citations

Jan 1, 1991·Rheumatology International·A D Blann, D G Scott
Dec 17, 2009·The Journal of Biological Chemistry·Steve MarchenkoSergei A Grando
Sep 1, 1991·Clinical and Experimental Dermatology·S A GrandoA B Romanenko
Feb 12, 2004·The Journal of Investigative Dermatology. Symposium Proceedings·Sergei A Grando
Mar 8, 2016·International Immunopharmacology·Soheil Tavakolpour
May 28, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·M G Pacheco-TovarR Herrera-Esparza
Sep 24, 2011·Autoimmunity·Sergei A Grando
Jul 6, 2021·Journal of Autoimmunity·Heather M RenNancy J Olsen

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