Oct 1, 1989

Autoreactive T-cell response to resting or activated B cells

Immunology
J MoynihanM Zauderer

Abstract

Cloned autoreactive T-cell lines and hybridomas have been selected in many laboratories. A number of observations have suggested that activation of Ia-positive stimulators may be required for optimal induction of an autoreactive response. We have examined the ability of small resting B cells fractionated by centrifugal elutriation to stimulate the proliferative response of seven cloned autoreactive T-cell lines. Of these, six were efficiently stimulated by resting B cells. One I-Ed-specific Th2-type T-cell clone failed to be stimulated by resting B cells. This clone did, however, respond to this same cell fraction following lipopolysaccharide (LPS) activation. An independent I-E-specific Th2 clone was stimulated by resting B cells. It appears, therefore, that a requirement for activated stimulators is not a general property of either autoreactive T cells or the Th2 helper T-cell subset.

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Mentioned in this Paper

T-Lymphocyte
Antigenic Specificity
Cell Communication
Lymphocyte Activation
B-Lymphocytes
Cell Fraction
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocyte
Lipopolysaccharides
Interphase Cell

About this Paper

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