Autoreactive T cells mediate NK cell degeneration in autoimmune disease

The Journal of Immunology : Official Journal of the American Association of Immunologists
Ruolan LiuFu-Dong Shi

Abstract

Emerging evidence indicates that NK cells play an important and complex role in autoimmune disease. Humans with autoimmune diseases often have reduced NK cell numbers and compromised NK cell functions. Mechanisms underlying this NK cell degeneration and its biological significance are not known. In this study we show that, in an experimental model of human autoimmune myasthenia gravis induced by a self-Ag, the acetylcholine receptor, NK cells undergo proliferation during the initiation of autoimmunity, followed by significant degeneration associated with the establishment of the autoreactive T cell response. We show that NK cell degeneration was mediated by IL-21 derived from autoreactive CD4(+) T cells, and that acetylcholine receptor-immunized IL-21R-deficient mice, with competent NK cells, developed exacerbated autoimmunity. Thus, NK cell degeneration may serve as a means evolved by the immune system to control excessive autoimmunity.

References

Mar 6, 1992·Cell·P MombaertsV E Papaioannou
Jul 1, 1990·Immunology Today·H G Ljunggren, K Kärre
Jan 1, 1989·Advances in Immunology·G Trinchieri
Dec 31, 1997·The Journal of Experimental Medicine·B ZhangT Tabira
May 29, 1998·European Journal of Immunology·Y MatsumotoN Tanuma
Mar 8, 2000·The Journal of Experimental Medicine·M K KennedyJ J Peschon
Mar 23, 2001·Nature Immunology·F D ShiH G Ljunggren
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F D ShiH G Ljunggren
Apr 5, 2001·Trends in Immunology·F D ShiN Sarvetnick
Apr 19, 2002·Brain : a Journal of Neurology·D BuljevacR Q Hintzen
Nov 26, 2002·Science·Katsutoshi OzakiWarren J Leonard
Dec 4, 2002·Nature Reviews. Immunology·Alessandro Moretta
Jun 6, 2003·Current Opinion in Immunology·Lewis L Lanier
Dec 31, 2003·Trends in Immunology·Megan A CooperMichael A Caligiuri
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bibiana BielekovaRoland Martin
Mar 23, 2004·Annual Review of Immunology·Wayne M YokoyamaAnthony R French
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Laurent PoirotDiane Mathis
Jun 11, 2004·Immunity·Kouetsu OgasawaraLewis L Lanier
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erika AssarssonBenedict J Chambers
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra ZingoniLewis L Lanier
Nov 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guido FerlazzoChristian Münz
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy L VollmerFu-Dong Shi

❮ Previous
Next ❯

Citations

Aug 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mark T OrrLewis L Lanier
Dec 3, 2014·Neuroscience Bulletin·Xiao-Dong KongFu-Dong Shi
Aug 21, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cun-Jin ZhangYaping Yan
Jun 3, 2016·Immunopharmacology and Immunotoxicology·Erandi Enif Velarde-de la CruzMaría Guadalupe Ramírez-Dueñas
Jan 10, 2018·Frontiers in Immunology·Emilie DugastSophie Brouard
Feb 7, 2014·Blood·Wei DuQishen Pang
Nov 19, 2010·Journal of Cutaneous Medicine and Surgery·Joanna NarbuttWojciech Młynarski
May 19, 2010·Expert Review of Clinical Immunology·Esin AktasGunnur Deniz
Sep 26, 2006·Nature Reviews. Immunology·Fu-Dong Shi, Luc Van Kaer
Aug 30, 2012·Scandinavian Journal of Immunology·W WuR Liu
Sep 24, 2011·Nature Reviews. Immunology·Fu-Dong ShiLuc Van Kaer
Mar 26, 2013·Cellular & Molecular Immunology·Isabela Pedroza-PachecoAurore Saudemont
Jun 8, 2013·International Journal of Molecular Sciences·Woon Yong ChoiHyeon Yong Lee
Apr 5, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jian-Ting LiHai-Qing Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
F D ShiNora Sarvetnick
The Journal of Immunology : Official Journal of the American Association of Immunologists
Jonathan M CoquetDale I Godfrey
Proceedings of the National Academy of Sciences of the United States of America
Jason A BubierDerry C Roopenian
© 2022 Meta ULC. All rights reserved