Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition.

Science
Jeff W ChenEric Meffre

Abstract

Restricted V(D)J recombination during fetal development was postulated to limit antibody repertoire breadth and prevent autoimmunity. However, newborn serum contains abundant autoantibodies, suggesting that B cell tolerance during gestation is not yet fully established. To investigate this apparent paradox, we evaluated the reactivities of more than 450 antibodies cloned from single B cells from human fetal liver, bone marrow, and spleen. We found that incomplete B cell tolerance in early human fetal life favored the accumulation of polyreactive B cells that bound both apoptotic cells and commensal bacteria from healthy adults. Thus, the restricted fetal preimmune repertoire contains potentially beneficial self-reactive innate-like B cell specificities that may facilitate the removal of apoptotic cells during development and shape gut microbiota assembly after birth.

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Citations

Sep 23, 2020·The Journal of Experimental Medicine·Emilie K Grasset, Andrea Cerutti
Mar 17, 2021·Autoimmunity Reviews·Yannick DieudonnéVincent Gies
Jan 14, 2021·Immunological Reviews·Elizabeth A Leadbetter, Mikael C I Karlsson
Jan 26, 2021·Médecine sciences : M/S·Virginie PascalMichel Cogné
Jan 26, 2021·American Journal of Respiratory and Critical Care Medicine·Susan V Lynch, Donata Vercelli
Jan 28, 2021·Immunological Reviews·Stefano Vergani, Joan Yuan
Feb 12, 2021·Nature Reviews. Immunology·Kelsey E HuusB Brett Finlay
Apr 28, 2021·Annual Review of Immunology·Eduard AnsaldoYasmine Belkaid
Oct 3, 2021·Nature Communications·Hector CorderoEmmanuel Zorn
Oct 7, 2021·The Journal of Experimental Medicine·Wendy FonsecaCatherine Ptaschinski

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