Autoreceptors mediate the inhibition of dopamine synthesis by bromocriptine and lisuride in rats

European Journal of Pharmacology
A H TissariG L Gessa

Abstract

The administration of bromocriptine and lisuride to rats caused a decrease in striatal dopamine (DA) synthesis, as measured by 3,4-dihydroxy-phenylalanine (DOPA) accumulation after decarboxylase inhibition. DOPA formation was inhibited by a maximum of about 60% of control values by bromocriptine and lisuride, 5.0 and 0.3 mg/kg, respectively. Both compounds showed very similar time-courses for the effect and failed to modify DOPA accumulation during the first 30 min. Pretreatment with (-)-sulpiride (50 mg/kg i.p.), a specific D2-receptor blocker, completely prevented the inhibitory effect of bromocriptine and lisuride on DOPA accumulation. Finally, both compounds significantly reversed the gamma-butyrolactone (GBL) (700 mg/kg i.p.)-induced DOPA accumulation at doses (0.25 and 0.015 mg/kg, respectively) that were inactive in normal rats. The data suggest that bromocriptine and lisuride act as agonists on D2-presynaptic autoreceptors which have different sensitivity to the agonist according to the basal firing rate of DA neurons.

References

Jan 1, 1977·Journal of Neural Transmission·J Y LewM Goldstein
Nov 24, 1979·Lancet·M SchachterJ D Parkes
Jul 15, 1976·Life Sciences·M TrabucchiL Frattola
Apr 1, 1976·European Journal of Pharmacology·R Horowski, H Wachtel
Jul 1, 1974·The Journal of Clinical Endocrinology and Metabolism·E Del PozoA Uettwiler
Sep 1, 1972·The Journal of Pharmacy and Pharmacology·W KehrC Atack
Nov 23, 1974·British Medical Journal·D B CalneA Petrie
Dec 17, 1981·European Journal of Pharmacology·S Arbilla, S Z Langer
Apr 1, 1981·Neurology·G GopinathanD B Calne
Jan 1, 1981·Annals of Neurology·J D ParkesA Wilson

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Citations

Jan 1, 1991·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·H Wachtel
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·T BrannanM D Yahr
Sep 1, 1985·Pharmacology, Biochemistry, and Behavior·L M Adams, M A Geyer
Aug 2, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caterina BreitensteinStefan Knecht
May 15, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Christopher D SwagellRoss McD Young
Oct 18, 2008·Schizophrenia Bulletin·John D RaglandAnthony D Wagner
Jun 2, 2009·Biochemical Pharmacology·Zhihua Xie, Gregory M Miller
Apr 25, 2008·Journal of Psychiatric Research·Diego A PizzagalliMaurizio Fava
Jun 21, 2013·Biology of Mood & Anxiety Disorders·Quentin Jm HuysPeter Dayan
Feb 7, 2012·ACS Chemical Neuroscience·Trisha L Vickrey, B Jill Venton

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