PMID: 18407220Sep 1, 1994Paper

Autoregulation and crossregulation of nuclear receptor genes

Trends in Endocrinology and Metabolism : TEM
J R Tata

Abstract

Whereas crossregulation of nuclear receptors has been known for some time, recently several examples of autoregulation have been described, especially during development and specific gene expression. In this review, I discuss both these phenomena, based on some studies from our laboratory on amphibian metamorphosis and egg protein gene expression. These include autoinduction of estrogen receptor (ER) accompanying egg protein gene expression in adult and larval Xenopus; autoinduction of thyroid hormone receptor (TR) during metamorphosis and in adult Xenopus; crossregulation by triiodothyronine (T(3)) and dexamethasone of autoinduction of ER; and inhibition by PRL of autoinduction and crossinduction of TR and ER genes. A dual receptor threshold model to explain the interplay between T(3), estrogen and PRL is presented and its significance to the general question of nuclear receptor autoregulation and crossregulation during development is also discussed.

References

Sep 1, 1992·Molecular and Cellular Endocrinology·I Machuca, J R Tata
Apr 1, 1992·Trends in Genetics : TIG·A J Andres, C S Thummel
Nov 1, 1991·Biochemical Society Transactions·S Green
Aug 1, 1990·Seminars in Liver Disease·R S Crowther, R D Soloway
Mar 11, 1987·Biochimica Et Biophysica Acta·R N Etindi, J A Rillema
Dec 1, 1984·Molecular and Cellular Endocrinology·A J PerlmanJ R Tata
Jan 1, 1993·Molecular and Cellular Endocrinology·N González-CadavidJ Rajfer
Apr 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J R Tata
Aug 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·J R TataK Yamauchi
Jul 1, 1993·Trends in Endocrinology and Metabolism : TEM·X K Zhang, M Kahl
May 1, 1994·Trends in Endocrinology and Metabolism : TEM·J A Rillema

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Citations

Dec 10, 1998·The Journal of Experimental Zoology·K Crawford, D M Vincenti
Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·R J Denver
May 12, 2006·Evolution & Development·Rachid SafiVincent Laudet
Nov 4, 2005·General and Comparative Endocrinology·Daniel R BuchholzYun-Bo Shi
Apr 2, 2014·General and Comparative Endocrinology·Paula Duarte-GutermanVance L Trudeau
Mar 22, 2019·Life Science Alliance·Nathalie PierrotJean-Noël Octave

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