PMID: 9178097Jun 15, 1997Paper

Autoregulation of actin synthesis responds to monomeric actin levels

Journal of Cellular Biochemistry
A LyubimovaA Ben-Ze'ev

Abstract

Regulation of the assembly and expression of actin is of major importance in diverse cellular functions such as motility and adhesion and in defining cellular and tissue architecture. These biological processes are controlled by changing the balance between polymerized (F) and soluble (G) actin. Previous studies have indicated the existence of an autoregulatory pathway that links the state of assembly and expression of actin, resulting in the reduction of actin synthesis after actin filaments are depolymerized. We have employed the marine toxins swinholide A and latrunculin A, both disrupting the organization of the actin-cytoskeleton, to determine whether this autoregulatory response is activated by a decrease in the level of polymerized actin or by an increase in monomeric actin concentrations in the cell. We showed that in cells treated with swinholide A the level of filamentous actin is decreased, and using a reversible cross-linking reagent, we found that actin dimers are formed. Latrunculin A also disassembled actin filaments, but produced monomeric actin, followed by a reduction in actin and vinculin expression, while swinholide A treatment elevated the synthesis of these proteins. In cells treated with both latrunculin ...Continue Reading

Citations

Dec 6, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jeyalakshmi SureshkumarBaohe Tian
Feb 5, 2008·In Vitro Cellular & Developmental Biology. Animal·Michele L MarquetteMarguerite Sognier
May 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Cynthia R WagnerKathryn G Miller
Dec 12, 2001·Molecular Biology of the Cell·M N CordonnierE Coudrier
Mar 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Laurin M HanftJames M Ervasti
Jun 24, 2017·Tuberculosis Research and Treatment·Flavia Silva PalomoAntonio Carlos Campos Pignatari

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