PMID: 2492410Feb 1, 1989Paper

Autoregulation of cerebral blood flow during normocapnia and hypocapnia in dogs

Anesthesiology
A A ArtruP S Colley

Abstract

The effect of hypocapnia on autoregulation of cerebral blood flow (CBF) and the lower limit of autoregulation (LLA) was determined in dogs anesthetized with nitrous oxide (66%) and halothane (0.2%, end-expired concentration). CBF and cerebral vascular resistance (CVR) were determined during both normocapnia and hypocapnia (PaCO2 21-22 mmHg) at control cerebral perfusion pressure (CPP) and after reducing CPP (by hemorrhage) to 80%, 60%, 50%, and 40% of control. At control CPP hypocapnia decreased CBF from 75 +/- 5 to 48 +/- 3 ml.100 g-1.min-1 (mean +/- SEM, P less than 0.05). During both normocapnia and hypocapnia CVR decreased and CBF did not change as CPP was reduced to 60% of control. When CPP was reduced to 50% or 40% of control, CVR remained decreased and CBF fell sharply. The LLA during hypocapnia, 61 +/- 2% of control CPP, was not different than that during normocapnia, 59 +/- 3% of control CPP. Below the LLA the CBF-CPP slopes differed from zero but did not differ between hypocapnia and normocapnia. Hypocapnia does not produce a substantial shift of the LLA, and over the range of CPP values studied here, autoregulatory cerebral vasodilation only partially abolishes hypocapnia-induced cerebral vasoconstriction. The result...Continue Reading

Citations

Jan 6, 2009·Journal of the American Animal Hospital Association·Susan M TaylorG Diane Shelton
Sep 26, 2003·Journal of Neurosurgical Anesthesiology·Monica S VavilalaArthur M Lam
May 30, 1998·Anesthesiology·J E Brian
Dec 18, 2013·Seminars in Pediatric Surgery·Robert C Tasker
Mar 15, 2016·Paediatric Respiratory Reviews·Jordan S RettigRobert C Tasker
Jan 1, 1991·Pediatric Neurology·J Del ToroJ Goddard-Finegold
Mar 3, 2015·Seminars in Pediatric Neurology·Robert C Tasker
Nov 18, 2014·Anesthesiology·Lingzhong Meng, Adrian W Gelb
Aug 10, 2021·Frontiers in Neurology·Darcy LidingtonSteffen-Sebastian Bolz

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