PMID: 8600117Sep 1, 1995Paper

Autoregulation of cochlear blood flow in the hydropic guinea pig

Hearing Research
P B BrechtelsbauerA L Nuttall

Abstract

Previous data suggest that regulation of cochlear blood flow (CBF) may be abnormal in the hydropic guinea pig. The purpose of this study was to employ the technique of anterior inferior cerebellar artery (AICA) occlusion to measure CBF autoregulation in experimental endolymphatic hydrops. This study also addresses the role of the cochlear sympathetic neural innervation and nitric oxide in CBF regulation with hydrops. In anesthetized guinea pigs, CBF was measured with a laser Doppler flowmeter probe while the AICA was intermittently occluded with a microvascular occluder. The CBF response was measured in normal, 6-week, and 12-week chronically hydropic animals. The gain factors (0 = no autoregulation, 1 = complete autoregulation) for 1-min occlusion were 0.95 +/- 0.16 (control), 0.77 +/- 0.28 (6 week, P = 0.164), and 0.67 +/- 0.25 (12 week, P = 0.037). NG-nitro-L-arginine methyl ester (L-NAME), a competitive inhibitor of nitric oxide synthase, was infused intravenously to assess basal nitric oxide (an endogenous vasodilator) production in the hydropic ear. With infusion of L-NAME, CBF was reduced by 9.16 +/- 11%, 10.7 +/- 10% (P = 0.87), and 16.6 +/- 18% (P = 0.95), in the control, 6-week, and 12-week animals, respectively. In a...Continue Reading

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Citations

Sep 23, 2003·Brain Research. Brain Research Reviews·Tsutomu NakashimaAlfred L Nuttall
Sep 3, 2002·Hearing Research·Hideaki HoshijimaHiroshi Takenaka
Sep 15, 2005·The Journal of the Acoustical Society of America·Katuhiro Maki, Shigeto Furukawa
Jun 10, 2008·The Journal of the Acoustical Society of America·Kanthaiah KokaDaniel J Tollin
Feb 12, 2009·The Journal of the Acoustical Society of America·Daniel J Tollin, Kanthaiah Koka
Aug 31, 2011·Hearing Research·Xiaorui Shi
Jul 13, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P G ReddyW S Quirk
Aug 11, 1999·The Journal of Comparative Neurology·J C MorrisD D Simmons
Aug 26, 1998·The Annals of Otology, Rhinology, and Laryngology·T SuzukiJ M Miller
Dec 12, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M A Kutlubaev, M V Zamergrad
Jul 9, 2008·Acta Oto-laryngologica·Nana AkagiMatti Anniko
Jun 15, 2019·Vestnik otorinolaringologii·M A KutlubaevA L Guseva
Oct 20, 2019·Medical Hypotheses·Brooke SarnaHamid R Djalilian
Mar 30, 2021·Frontiers in Neurology·Sun-Young OhValerie Kirsch

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