Autoregulation of subtilin biosynthesis in Bacillus subtilis: the role of the spa-box in subtilin-responsive promoters

Peptides
M KleerebezemO P Kuipers

Abstract

The production of the type I antimicrobial peptide (AMP) subtilin by Bacillus subtilis is regulated in a cell-density-dependent manner [Kleerebezem M, de Vos WM, Kuipers OP. The lantibiotics nisin and subtilin act as extracellular regulators of their own biosynthesis. In: Dunny GM, Winans SC, editors. Cell-cell signaling in bacteria. Washington, D.C., USA: ASM Press; 1999. p. 159-74; Stein T, Borchert S, Kiesau P, Heinzmann S, Kloss S, Klein C, Helfrich M, Entian KD. Dual control of subtilin biosynthesis and immunity in Bacillus subtilis. Mol Microbiol 2002;44:403-16; Stein T, Heinzmann S, Kiesau P, Himmel B, Entian KD. The spa-box for transcriptional activation of subtilin biosynthesis and immunity in Bacillus subtilis. Mol Microbiol 2003;47:1627-36]. Three subtilin-responsive promoter elements within the spaBTCSIFEGRK are controlled by the specific cis-acting sequence element called the spa-box, which represents the binding site of the subtilin regulator SpaR [Stein T, Heinzmann S, Kiesau P, Himmel B, Entian KD. The spa-box for transcriptional activation of subtilin biosynthesis and immunity in Bacillus subtilis. Mol Microbiol 2003;47:1627-36]. Here, we describe the functional characterization of the spaB, spaS and spaI promo...Continue Reading

References

Nov 24, 1979·Nucleic Acids Research·H C Birnboim, J Doly
Jan 1, 1992·Applied and Environmental Microbiology·C KleinK D Entian
Nov 10, 1995·The Journal of Biological Chemistry·O P KuipersW M de Vos
Aug 1, 1994·Applied and Environmental Microbiology·C Klein, K D Entian
Jan 1, 1993·Journal of Cellular Biochemistry·B L Wanner
Jan 1, 1993·Applied and Environmental Microbiology·C KleinK D Entian
Jun 1, 1996·Journal of Bacteriology·P G de RuyterW M de Vos
Feb 1, 1996·Antonie van Leeuwenhoek·R J SiezenW M de Vos
Oct 1, 1996·Applied and Environmental Microbiology·P G de RuyterW M de Vos
Oct 1, 1996·Antonie van Leeuwenhoek·I F NesH Holo
Mar 1, 1997·Journal of Bacteriology·P KiesauK D Entian
Jan 1, 1997·Annual Review of Microbiology·G M Dunny, B A Leonard
Apr 26, 2002·Molecular Microbiology·Torsten SteinKarl-Dieter Entian
Mar 8, 2003·Molecular Microbiology·Torsten SteinKarl-Dieter Entian
Apr 23, 2003·Biochemical and Biophysical Research Communications·Carsten CorveyKarl-Dieter Entian

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Citations

Aug 10, 2005·Applied Microbiology and Biotechnology·Igor Mierau, Michiel Kleerebezem
Sep 19, 2006·Applied and Environmental Microbiology·Stephanie SchmitzGabriele Bierbaum
Mar 5, 2005·Applied and Environmental Microbiology·Richard van KranenburgMichiel Kleerebezem
Apr 6, 2007·Plasmid·Louis B RiceSusan Rudin
Aug 25, 2005·Current Opinion in Microbiology·Gregory C Patton, Wilfred A van der Donk
Sep 24, 2015·Microbial Cell Factories·Chengran GuanZhemin Zhou
Aug 11, 2010·FEMS Microbiology Reviews·Hikmate AbriouelAntonio Gálvez
Sep 25, 2010·Research in Microbiology·Ludmila VavrováImrich Barák
Sep 12, 2018·World Journal of Microbiology & Biotechnology·Wenjing CuiZhemin Zhou
Jun 11, 2019·Frontiers in Microbiology·Alexey S Vasilchenko, Eugene A Rogozhin
Feb 11, 2005·Chemical Reviews·Champak ChatterjeeWilfred A van der Donk

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