Autoregulation of total and zonal glomerular filtration rate in spontaneously hypertensive rats during antihypertensive therapy

Journal of Cardiovascular Pharmacology
X WangB M Iversen

Abstract

The effects of angiotensin II type 1 receptor antagonist (losartan), angiotensin 1-converting enzyme (ACE) inhibitor (enalapril), and calcium channel blocker (nifedipine) on autoregulation of total and zonal glomerular filtration rate (GFR) were studied in spontaneously hypertensive rats (SHRs), 10 and 40 weeks of age, and 10-week-old Wistar-Kyoto (WKY) rats. Untreated animals in each group served as controls. Renal blood flow (RBF) was measured by a transit-time flow probe (Transonic) on the left renal artery. Total and zonal GFR (outer, middle, and inner cortex) were estimated from tubular uptake of 125iodine-labeled aprotinin (125IAp) injected i.v. at control renal arterial pressure (RAP), and 131IAp injected at a RAP reduced to the lower limit of RBF autoregulation. Autoregulation of RBF was reset to higher pressure levels in untreated hypertensive rats. Enalapril normalized this resetting in 10-week-old SHRs, but not in aged SHRs 40 weeks. Losartan did not completely normalize this resetting in either 10-or 40-week-old SHRs, whereas nifedipine impaired RBF autoregulation in both WKYs and SHRs. A decreased autoregulatory compensation of GFR after pressure reduction was observed in losartan-treated 10-week-old SHRs and after...Continue Reading

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Citations

Jun 5, 2003·Journal of Structural Biology·Dadash BaranKnut Aukland
Dec 15, 2015·Pflügers Archiv : European journal of physiology·Rasmus Hassing FrandsenCharlotte Mehlin Sorensen
Jan 6, 2017·Channels·Lars Jørn JensenCharlotte Mehlin Sørensen
Apr 4, 2012·Journal of Hypertension·Michael Hultström
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Aug 13, 1998·Journal of Cardiovascular Pharmacology·F J López-HernándezR Carrón
May 5, 1999·Journal of Cardiovascular Pharmacology·F J López-HernándezM A Arévalo
May 12, 2020·American Journal of Physiology. Renal Physiology·Elisa P JensenCharlotte M Sorensen
Jan 20, 2000·Current Medical Research and Opinion·E O SchraaJ N IJzermans
Jun 29, 2007·American Journal of Physiology. Renal Physiology·Liliana Monica BivolBjarne Magnus Iversen

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