Autoregulation of total and zonal glomerular filtration rate in spontaneously hypertensive rats with mesangiolysis

Kidney & Blood Pressure Research
X WangB M Iversen

Abstract

In this study we tested the hypothesis that mesangial cells participate in autoregulation of the glomerular filtration rate (GFR) in normotensive and hypertensive rats. Mesangial cell lesions were induced by intravenous administration of antithymocyte (anti-Thy 1.1) antibodies in spontaneously hypertensive rats (SHR) and in Wistar-Kyoto rats (WKY). Normal murine serum was injected in control rats. Hemodynamic measurements were performed 24 h after the infusion of the anti-Thy 1.1 antibodies. Renal blood flow (RBF) was measured by a transit time flowmeter (Transonic) and the GFR was measured as the uptake of 125 iodine-labeled aprotinin ([125]I-Ap) by proximal tubular cells at the control renal arterial pressure and (131)I-Ap at a pressure reduction close to the lower pressure limit of RBF autoregulation. RBF was unaltered and the autoregulatory capability was maintained in SHR and WKY after mesangial cell lesions. Mesangiolysis significantly reduced the total GFR in normotensive, but not in hypertensive animals. The fractional compensation of the GFR was attenuated in the outer cortical layer (p<0.05) in normotensive WKY. In SHRs the fractional compensation of the GFR was impaired in all cortical layers after mesangiolysis, sli...Continue Reading

Citations

Jul 23, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Magali AraujoKenneth L Becker
Jan 5, 2007·Journal of the American Society of Nephrology : JASN·Takahiko NakagawaByron Croker
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst

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