Autosomal Dominant Polycystic Kidney Disease and Intracranial Aneurysms: Is There an Increased Risk of Treatment?

AJNR. American Journal of Neuroradiology
M N RozenfeldM C Hurley

Abstract

Autosomal dominant polycystic kidney disease is associated with an increased risk of intracranial aneurysms. Our purpose was to assess whether there is an increased risk during aneurysm coiling and clipping. Data were obtained from the National Inpatient Sample (2000-2011). All subjects had an unruptured aneurysm clipped or coiled and were divided into polycystic kidney (n = 189) and control (n = 3555) groups. Primary end points included in-hospital mortality, length of stay, and total hospital charges. Secondary end points included the International Classification of Diseases, Ninth Revision codes for iatrogenic hemorrhage or infarction; intracranial hemorrhage; embolic infarction; and carotid and vertebral artery dissections. There was a significantly greater incidence of iatrogenic hemorrhage or infarction, embolic infarction, and carotid artery dissection in the patients with polycystic kidney disease compared with the control group after endovascular coiling. There was also a significantly greater incidence of iatrogenic hemorrhage or infarction in the polycystic kidney group after surgical clipping. However, the hospital stay was not longer in the polycystic kidney group, and the total hospital charges were not higher. Ad...Continue Reading

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Citations

Jun 4, 2016·AJNR. American Journal of Neuroradiology·A RouchaudW Brinjikji
Oct 27, 2016·Journal of Nephrology·Piergiorgio MessaRoberta Cerutti
Aug 28, 2017·Neurologia i neurochirurgia polska·Mariusz NiemczykLeszek Pączek
Jun 21, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Adrien Flahault, Dominique Joly
Aug 1, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Irina M SanchisVicente E Torres
Dec 14, 2018·Nature Reviews. Disease Primers·Carsten BergmannVicente E Torres

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