Autosomal dominant polycystic kidney disease reduces the risk of diabetes mellitus

Archives of Medical Research
Maria Pietrzak-NowackaK Ciechanowski

Abstract

Patients with autosomal dominant polycystic kidney disease (ADPKD) are at greater risk of new-onset diabetes after transplantation as compared with other renal graft recipients. We mailed questionnaires to 459 ADPKD patients retrieved from the Polish Registry of ADPKD. We analyzed data from 291 respondents and 271 siblings with a known status of ADPKD and diabetes. The prevalence of transplant-unrelated diabetes was significantly higher in siblings without ADPKD (8.2%) than in respondents (1.7%; p = 0.0028) and their ADPKD siblings (2.0%; p = 0.023). Univariate logistic regression demonstrated that the prevalence odds ratio (POR) for transplant-unrelated diabetes in the pooled ADPKD group vs. siblings without ADPKD was 0.21 (95% CI: 0.08-0.54, p = 0.0013). Multivariate regression accounting for age and gender disclosed an even smaller POR for diabetes (0.18) in ADPKD patients (95% CI: 0.07-0.47, p = 0.00049). Age was a significant risk factor for diabetes (POR 1.05, 95% CI: 1.01-1.09 per year of life; p = 0.025) and gender was without effect. The prevalence of diabetes in females and males with vs. without ADPKD was similar (1.6% vs. 8.3%, p = 0.0091 for females; 2.2% vs. 8.0%, p = 0.069 for males). Age and gender were not inte...Continue Reading

References

Jan 1, 1990·Blood Purification·F KokotA Wiecek
Jul 1, 1997·Diabetologia·M StumvollJ E Gerich
Aug 1, 1997·Kidney International·K VareesangthipT H Thomas
May 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D DuclouxJ M Chalopin
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alberto MontoliFabrizio Barbetti
Aug 26, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dominique JolyBertrand Knebelmann

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Citations

Dec 31, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Berenice ReedRobert W Schrier
Apr 21, 2009·Transplantation Proceedings·S GonçalvesA Gomes da Costa
May 26, 2010·Nature Reviews. Nephrology·Adnan Sharif, Keshwar Baboolal
Oct 22, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Maria Pietrzak-NowackaKazimierz Ciechanowski

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