Autotransplantation of Monkey Ear Perichondrium-Derived Progenitor Cells for Cartilage Reconstruction

Cell Transplantation
Shintaro KagimotoHideki Taniguchi

Abstract

We recently developed a promising regenerative method based on the xenotransplantation of human cartilage progenitor cells, demonstrating self-renewing elastic cartilage reconstruction with expected long-term tissue restoration. However, it remains unclear whether autotransplantation of cartilage progenitors may work by a similar principle in immunocompetent individuals. We used a nonhuman primate (monkey) model to assess the safety and efficacy of our regenerative approach because the model shares characteristics with humans in terms of biological functions, including anatomical features. First, we identified the expandable and multipotent progenitor population from monkey ear perichondrium and succeeded in inducing chondrocyte differentiation in vitro. Second, in vivo transplanted progenitor cells were capable of reconstructing elastic cartilage by xenotransplantation into an immunodeficient mouse. Finally, the autologous monkey progenitor cells were transplanted into the subcutaneous region of a craniofacial section and developed mature elastic cartilage of their own 3 months after transplantation. Furthermore, we attempted to develop a clinically relevant, noninvasive monitoring method using magnetic resonance imaging (MRI)...Continue Reading

References

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Citations

Oct 16, 2018·The Journal of Craniofacial Surgery·Qing-Chun FanXu-Kai Wang
Feb 16, 2019·Stem Cells International·Ihsène TaïhiFrançois Ferré
Aug 31, 2020·Laryngoscope Investigative Otolaryngology·Weston L NiermeyerTendy Chiang
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Eleonora ZucchelliPatrizia Ferretti
Dec 22, 2019·Applied Biochemistry and Biotechnology·Xueyan HuKedong Song
Feb 23, 2020·Biochemistry Research International·Xiangbo MengXinluan Wang
May 8, 2021·Journal of Tissue Engineering·Aala'a Emara, Rishma Shah

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Methods Mentioned

BETA
dissection
Assay
sedation

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