PMID: 2497171Mar 1, 1989Paper

Auxiliary liver transplantation in jaundiced rats with UDP-glucuronyltransferase deficiency and defective hepatobiliary transport

Journal of Hepatology
P L JansenF H Corstens

Abstract

In this study auxiliary liver transplantation (ALT) has been tested as a means of correcting the UDP-glucuronyltransferase deficiency in Gunn rats and the UDP-glucuronyltransferase deficiency and impaired hepatobiliary bilirubin transport in double mutant rats. In both groups serum bilirubin normalized and remained low until the end of the study at 12 weeks after transplantation in 4 out of 6 rats. Excretion of 99mTc-HIDA in non-transplanted double mutants was considerably slower than in Gunn rats (kel 0.9 x 10(-3) versus 4.3 x 10(-3) s-1). HIDA excretion by transplants in double mutants and Gunn rats was about equal (kel 1.6 x 10(-3) and 1.1 x 10(-3) s-1). Experiments with bile duct-cannulated transplants showed that in double mutants bile flow, bile acid and bilirubin excretion was 2-4 times higher than in Gunn rats. This study shows that auxiliary liver transplants can conjugate and excrete bilirubin when one of these or both functions are lacking in the recipient's liver.

References

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Citations

Sep 25, 1993·Lancet·P F WhitingtonJ R Thistlethwaite
Apr 20, 2004·Toxicology Letters·Naoki KiyosawaNaochika Matsunuma
Aug 2, 2003·Journal of Pediatric Surgery·Rolf SchauerHorst G Rau
Feb 1, 1997·Transplantation Proceedings·M RelaN D Heaton
Jan 1, 1995·Transplant International : Official Journal of the European Society for Organ Transplantation·M RelaK C Tan
Jul 4, 2007·Clinics in Liver Disease·Nanda Kerkar, Sukru Emre
Aug 19, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M RelaN Heaton

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