Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells

The European Journal of Neuroscience
Takahiro YasudaGerald W Zamponi

Abstract

The effects of auxiliary calcium channel subunits on the expression and functional properties of high-voltage activated (HVA) calcium channels have been studied extensively in the Xenopus oocyte expression system, but are less completely characterized in a mammalian cellular environment. Here, we provide the first systematic analysis of the effects of calcium channel beta and alpha(2)-delta subunits on expression levels and biophysical properties of three different types (Ca(v)1.2, Ca(v)2.1 and Ca(v)2.3) of HVA calcium channels expressed in tsA-201 cells. Our data show that Ca(v)1.2 and Ca(v)2.3 channels yield significant barium current in the absence of any auxiliary subunits. Although calcium channel beta subunits were in principle capable of increasing whole cell conductance, this effect was dependent on the type of calcium channel alpha(1) subunit, and beta(3) subunits altogether failed to enhance current amplitude irrespective of channel subtype. Moreover, the alpha(2)-delta subunit alone is capable of increasing current amplitude of each channel type examined, and at least for members of the Ca(v)2 channel family, appears to act synergistically with beta subunits. In general agreement with previous studies, channel activa...Continue Reading

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Citations

Dec 28, 2010·Nature Neuroscience·Christophe AltierGerald W Zamponi
Sep 10, 2010·The Journal of Biological Chemistry·Vicenta Salvador-Recatalà, Robert M Greenberg
Mar 16, 2011·The Journal of Biological Chemistry·María A GandiniRicardo Felix
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