PMID: 12765449May 27, 2003Paper

AV nodal ablation and pacemaker implantation improves hemodynamic function in atrial fibrillation

Pacing and Clinical Electrophysiology : PACE
Yoshihide TakahashiAblation and Pacing Therapy Working Group

Abstract

In drug refractory and highly symptomatic atrial fibrillation (AF) patients, hemodynamic effects of AV node ablation and pacing therapy (APT) were evaluated. Thirty-eight patients with drug refractory and symptomatic AF, underwent APT in eight centers in Japan. The outcome of this therapy was assessed in terms of quality-of-life, cardiac performance measured by echocardiogram, and plasma ANP and BNP levels before and after APT. Quality-of-life assessed by self-administered semi-quantitative questionnaires: WHO QOL 26 (3.0 +/- 0.5 vs 3.4 +/- 0.6, P < 0.01) and the Symptom Checklist: Frequency Scale (1.6 +/- 0.6 vs 0.7 +/- 0.7, P < 0.01) and Severity Scale (1.3 +/- 0.4 vs 0.6 +/- 0.6, P < 0.01), improved significantly 6 months after APT. Ejection fraction (EF) by echocardiogram improved 1 week after APT (59.0% +/- 13.3% vs 63.3% +/- 11.6%, P = 0.02). Plasma ANP levels in the group of ANP > 40 pg/mL at enrollment significantly decreased 1 month later (P = 0.03), and plasma BNP levels in the group of BNP > 20 pg/mL at enrollment significantly decreased 1 month later (P < 0.01). In conclusion, APT has beneficial hemodynamic effects, and plasma BNP levels can predict the most optimal candidates for ablation and pacing therapy.

References

Mar 1, 1986·The American Journal of Cardiology·D L PackerL D German
Jan 28, 1982·The New England Journal of Medicine·J J GallagherG Critelli
Jan 1, 1993·Journal of the American College of Cardiology·F MoradyS J Kalbfleisch
Mar 1, 1993·Journal of the American College of Cardiology·J E Olgin, M M Scheinman
Dec 15, 1996·The American Journal of Cardiology·E G DaoudF Morady
Oct 8, 1997·Journal of the American College of Cardiology·D M ClarkG N Kay
Jan 20, 1998·Lancet·T A McDonaghH J Dargie
Apr 12, 2000·Journal of the American College of Cardiology·A RossiJ B Seward
Sep 19, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·R Latini, S Masson

❮ Previous
Next ❯

Citations

May 17, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Brigitte LampeAlexander Yang
Jan 29, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Etienne AliotPaulus Kirchhof
Jan 15, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Kimberly L Skidmore, Isobel A Russell
Jan 22, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ru-Xing WangWin-Kuang Shen
Dec 22, 2011·Circulation. Arrhythmia and Electrophysiology·Neal A ChatterjeeJagmeet P Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.