PMID: 2112627Mar 1, 1990Paper

Availability of cysteine and of L-2-oxo-thiazolidine-4-carboxylic acid as a source of cysteine in intravenous nutrition

JPEN. Journal of Parenteral and Enteral Nutrition
L Bjelton, G B Fransson

Abstract

Cysteine is usually not included in amino acid solutions for intravenous nutrition for two reasons: it is not considered to be an essential amino acid, and it causes stability problems in solutions. The cysteine content of a solution decreases markedly in the presence of oxygen and/or glucose due to formation of various derivatives, such as cystine and D-glucocysteine. It is not clear if the formed derivatives are available for metabolic processes. A cysteine analogue, L-2-oxothiazolidine-4-carboxylic acid (OTCA), is stable in solutions and can be metabolized in the body-yielding cysteine. The metabolic availability of cysteine and OTCA from an all-in-one total parenteral nutrition (TPN) mixture was evaluated in the rat and compared to a regimen with cysteine infused from a separate container. A cysteine-free TPN mixture served as a control. All mixtures contained a suboptimal amount of methionine, which can normally be metabolized to cysteine, to enhance the nutritional effect of cysteine or OTCA supplement. The cysteine content in the admixture decreased approximately 40% during 30 hr after mixing. Nevertheless the utilization of this admixture was identical to the regimen supplying cysteine separately. The admixture containi...Continue Reading

Citations

Feb 1, 1993·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·G Grimble
Jun 1, 1993·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·M S Dahn
Oct 21, 2006·The Cochrane Database of Systematic Reviews·L M Soghier, L P Brion

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