PMID: 2112639May 1, 1990Paper

Availability of insulin from total parenteral nutrition solutions

JPEN. Journal of Parenteral and Enteral Nutrition
S P MarcuardJ F Caro

Abstract

Insulin is frequently required in total parenteral nutrition (TPN) solutions to control hyperglycemia. The purpose of this study was to evaluate the recovery of human insulin from standard TPN solutions with and without lipids and from TPN solutions with specialized amino acid formulations and to compare it to the insulin recovery from normal saline. All solutions were mixed in currently utilized PVC-free bags (ethylene vinyl acetate) and drained through PVC-containing tubing. Human insulin (Humulin-R) was spiked with 125I-labeled insulin and then added in concentrations of 10, 25, and 50 units to 1-liter bags containing 39-g amino acids (10% Freamine-III; or 6.9% Freamine HBC; or 8% Hepatamine), 257-g dextrose, electrolytes (Hyperlyte-R), 1000 units of heparin, MVI-12, and MTE-5 Concentrate. Alternate sets of bags contained 125 ml of 20% Intralipid and an appropriate amount of sterile water to keep the final volume at 1 liter. Actual clinical conditions of preparation, storage, and administration were simulated in this in vitro experiment. Multiple samples were collected during the 8-hr infusion period directly in gamma counter vials. All experiments and assays were done in triplicate. Our findings indicate that human insulin ...Continue Reading

Citations

Mar 6, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Loris PironiUNKNOWN Home Artificial Nutrition & Chronic Intestinal Failure Special Interest Group of ESPEN
Feb 1, 1996·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M A ValeroM Leon-Sanz
Jan 3, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Matthew A ChristiansonNorman Suzuki
Dec 1, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Zdenek RusavýOndrej Topolcan
Mar 31, 2017·Analytical and Bioanalytical Chemistry·Héloïse HenryPascal Odou
Feb 18, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph I BoullataUNKNOWN American Society for Parenteral and Enteral Nutrition
Jul 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·B Dunham, S P Marcuard
Apr 6, 2001·AACN Clinical Issues·P WorthingtonB A Wagner
Jul 13, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Maria Luisa ForchielliGermana Bersani
Oct 26, 2012·AACN Advanced Critical Care·Anne Gargasz
Aug 10, 2017·JPEN. Journal of Parenteral and Enteral Nutrition·Adam McCullochJeremy M Woodward
May 29, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Jyoti M Benni, Paragouda A Patil
Jan 1, 2016·Journal of Food and Drug Analysis·Kuo-Hua YuChung-Yu Chen
Mar 1, 1991·DICP : the Annals of Pharmacotherapy·D F DriscollB R Bistrian
Apr 9, 2021·Nutrición hospitalaria·Francisco Martínez de la TorrePilar Gomis Muñoz
Jan 1, 1991·Annales Françaises D'anesthèsie Et De Rèanimation·M RaucoulesD Grimaud

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