Availability of the serotonin transporter in patients with alcohol dependence

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Pei-Shen HoSan-Yuan Huang

Abstract

Evidence has suggested that the serotonin transporter (SERT) plays a role in the pathogenesis of alcohol dependence, anxiety and depression and that polymorphisms of the serotonin-transporter-linked promoter region (5-HTTLPR) may influence the SERT. This study evaluated the differences in SERT availability between healthy controls and alcoholic patients and the impact of 5-HTTLPR polymorphisms on SERT availability. Eleven healthy controls and 28 alcoholic patients were recruited. SERT availability was measured in vivo with single photon emission computed tomography and (123)I-labelled 2-((2-((dimethyl-amino)methyl)phenyl)thio)-5-iodophenylamine in the midbrain, thalamus and striatum. Each subject was genotyped for the 5-HTTLPR polymorphism. Compared to healthy controls, there was a significantly lower availability of SERT in the midbrain among patients with pure alcohol dependence (pure ALC). Of patients with anxiety, depression and alcohol dependence (ANX/DEPALC), the carriers of one L(A) allele showed a significantly higher availability of SERT in the striatum compared to non-L(A) carriers. After Bonferroni correction, these significances vanished. There were no significant differences in SERT availability between controls an...Continue Reading

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Citations

Apr 2, 2011·Journal of Gastroenterology and Hepatology·Tadayuki OshimaHiroto Miwa
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May 14, 2016·Deutsches Ärzteblatt International·Anil BatraAndreas Heinz

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