Avascular osteonecrosis of the femoral head in three West African HIV-infected adults with heterozygous sickle cell disease

Antiviral Therapy
Serge EholiéEmmanuel Bissagnene

Abstract

Three men (aged 33, 44 and 45 years, CD4(+) T-cell nadir 86 cells/mm(3), 99 cells/mm(3) and 12 cells/mm(3), respectively) were admitted to the Department of Infectious Diseases (Treichville Hospital, Abidjan, Côte d'Ivoire) for hip pain and impaired mobility. Their last available CD4(+) T-cell counts were 243 cells/mm(3), 245 cells/mm(3) and 8 cells/mm(3), respectively. They had all received antiretroviral therapy for >4 years, including lopinavir/ritonavir for >8 months. The other risk factors were hypertriglyceridaemia (n=3), smoking addiction (n=2), alcohol consumption (n=2) and lipodystrophy (n=1). All three patients had heterozygous haemoglobin AS sickle cell disease (percentage of haemoglobin S 41%, 45% and 50%, respectively). The diagnosis of avascular osteonecrosis of the femoral head (unilateral n=2 and bilateral n=1) was documented by CT scan. Only one patient underwent surgical arthroplasty. In resource-limited settings, avascular osteonecrosis is uneasy to diagnose and unlikely to be appropriately treated. Physicians should be aware of its symptoms and risk factors, including HIV infection and antiretroviral therapy. Future studies should explore whether these risk factors might include haemoglobin AS sickle cell di...Continue Reading

Citations

Apr 6, 2012·Archives of Orthopaedic and Trauma Surgery·Karl WieserClaudio Dora
Sep 5, 2012·Journal of the International AIDS Society·Serge-Paul EholiéXavier Anglaret
Dec 18, 2012·Arthritis·Jesse SeamonQuanjun Cui
Oct 26, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ewurama D A OwusuMartin P Grobusch
Aug 29, 2020·BMC Infectious Diseases·André Rolim BelisárioUNKNOWN Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) International Component Brazil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Robert E MarxVishtasb Broumand
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Cesar A Migliorati
Annals of the New York Academy of Sciences
M Angastiniotis, B Modell
© 2022 Meta ULC. All rights reserved