Avatrombopag Before Procedures Reduces Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia

Gastroenterology
Norah TerraultTarek Hassanein

Abstract

Patients with thrombocytopenia and chronic liver disease (CLD) may require platelet transfusions before scheduled procedures to decrease risk of bleeding. We performed 2 randomized, placebo-controlled, phase 3 trials in patients with thrombocytopenia and CLD undergoing scheduled procedures to evaluate the safety and efficacy of avatrombopag in increasing platelet counts in this patient population. In the ADAPT-1 and ADAPT-2 studies, adults with thrombocytopenia and CLD (n = 231 and n = 204, respectively) were in 1 of 2 cohorts according to their baseline platelet count (below 40 × 109/L or 40 to below 50 × 109/L) and within each cohort were randomized (2:1) to receive 5 daily doses of avatrombopag (60 mg if baseline platelet count below 40 × 109/L or 40 mg if 40 to below 50 × 109/L) or placebo. ADAPT-1 was conducted at 75 study sites in 20 countries, from February 2014 through January 2017, and ADAPT-2 was conducted at 74 sites in 16 countries, from December 2013 through January 2017. The primary endpoint was the proportion of patients not requiring platelet transfusions or rescue procedures for bleeding up to 7 days after a scheduled procedure. In the ADAPT-1 study, 65.6% of patients who received 60 mg avatrombopag and 88.1% o...Continue Reading

References

Apr 1, 1991·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M F Murphy, A H Waters
Jul 27, 2000·American Journal of Hematology·K R MeehanK A Schulman
Oct 29, 2000·The American Journal of Gastroenterology·F N BashourK D Mullen
Nov 9, 2001·The Oncologist·G D Demetri
Dec 21, 2005·Journal of Hepato-biliary-pancreatic Surgery·Masayuki OhtaSeigo Kitano
Apr 14, 2006·Alimentary Pharmacology & Therapeutics·E G Giannini
Nov 21, 2007·Hematology·Sherrill J Slichter
Nov 30, 2007·The New England Journal of Medicine·James B BusselJulian M Jenkins
Apr 25, 2008·Journal of Hepatology·Nezam AfdhalRafael Esteban
Jun 20, 2008·Transfusion·Jean-Louis H KerkhoffsAnneke Brand
Jul 16, 2008·Experimental Hematology·Mari Fukushima-ShintaniTomihisa Kawasaki
Feb 3, 2009·European Journal of Haematology·Mari Fukushima-ShintaniTatsutoshi Nakahata
Feb 27, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C RockeyUNKNOWN American Association for the Study of Liver Diseases
Apr 28, 2009·Journal of Vascular and Interventional Radiology : JVIR·Patrick C MalloyUNKNOWN Standards of Practice Committee with Cardiovascular and Interventional Radiological Society of Europe (CIRSE) Endorsement
Feb 19, 2010·The New England Journal of Medicine·Sherrill J SlichterSuzanne Granger
Apr 7, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Leonard B SeeffUNKNOWN HALT–C Trial Group
Jul 6, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Edoardo G GianniniVincenzo Savarino
Apr 20, 2012·Journal of Vascular and Interventional Radiology : JVIR·Indravadan J PatelUNKNOWN Standards of Practice Committee, with Cardiovascular and Interventional Radiological Society of Europe (CIRSE) Endorsement
Aug 24, 2012·The New England Journal of Medicine·Nezam H AfdhalUNKNOWN ELEVATE Study Group
Dec 10, 2013·Hematology·Zbigniew M Szczepiorkowski, Nancy M Dunbar
Mar 15, 2014·World Journal of Gastroenterology : WJG·Hiromitsu HayashiHideo Baba
Sep 16, 2014·Canadian Journal of Gastroenterology & Hepatology·V G R GangireddyT Coleman
Oct 1, 2015·Asian Journal of Transfusion Science·Serena ValsamiMarianna Politou
Dec 19, 2016·European Journal of Internal Medicine·Grazia NapolitanoAngelo Andriulli
Dec 23, 2016·British Journal of Haematology·Lise J EstcourtUNKNOWN British Committee for Standards in Haematology
Nov 29, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles A SchifferKenneth C Anderson

❮ Previous
Next ❯

Citations

Jul 12, 2018·Drugs·Matt Shirley
Feb 26, 2019·Expert Review of Clinical Immunology·Monika Długosz-DaneckaWojciech Jurczak
Feb 15, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Markus Peck-RadosavljevicNezam Afdhal
Jul 30, 2019·Expert Review of Clinical Pharmacology·Hongming Xu, Rong Cai
Jun 23, 2019·International Journal of Molecular Sciences·Page Clemons Bankston, Rami A Al-Horani
Oct 30, 2019·European Journal of Haematology·Patricia LiuJoseph Shatzel
Feb 23, 2020·Journal of Intensive Care Medicine·Nicholas W LangeRobert S Brown
Sep 7, 2019·European Journal of Gastroenterology & Hepatology·Peter Aiden McCormick, James R Docherty
Mar 7, 2020·Current Opinion in Gastroenterology·Matthew J StottsNeeral L Shah
Jun 9, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshihiro FuruichiTakao Itoi
Jul 15, 2020·Journal of the Royal Society of Medicine·Benjamin L Mazer
Nov 14, 2019·Surgery Today·Kazuhiro TakahashiNobuhiro Ohkohchi
Aug 25, 2020·Journal of Clinical and Translational Hepatology·Sarah Rawi, George Y Wu
Aug 21, 2020·Seminars in Thrombosis and Hemostasis·Saro Khemichian, Norah A Terrault
Aug 7, 2020·Seminars in Thrombosis and Hemostasis·Lara N Roberts, William Bernal
Aug 21, 2020·Seminars in Thrombosis and Hemostasis·Matthew J StottsNicolas M Intagliata
Jan 29, 2020·Research and Practice in Thrombosis and Haemostasis·Jennifer Gill, Vinay Prasad
May 10, 2020·International Journal of Molecular Sciences·Marie-Astrid van DievoetXavier Stephenne
Aug 7, 2020·Seminars in Thrombosis and Hemostasis·Patrick Northup, Jessica Davis
Apr 23, 2019·Therapeutic Advances in Hematology·Hanny Al-Samkari, David J Kuter
Jan 3, 2020·The American Journal of Gastroenterology·Douglas A SimonettoPatrick S Kamath
Apr 24, 2019·Digestive Diseases and Sciences·Sammy Saab, Robert S Brown
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Bibek AryalYutaka Imoto
Nov 9, 2019·Hepatology Communications·Kathy M NillesSteven L Flamm
Sep 29, 2020·ClinicoEconomics and Outcomes Research : CEOR·Deirdre MladsiRay Kim
Nov 26, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·María Luisa Lozano
Apr 3, 2020·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hirohito TakeuchiTakao Itoi
Nov 22, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick G NorthupDominique C Valla
Jul 28, 2020·La Revue de médecine interne·M EbboB Godeau
Feb 2, 2021·European Journal of Clinical Investigation·Edoardo Giovanni GianniniNezam Afdhal
Oct 24, 2020·Expert Opinion on Pharmacotherapy·Zain Mohammad VirkHanny Al-Samkari
Feb 13, 2021·Platelets·Pamela CzajkaCeren Eyileten
Nov 10, 2020·Clinical Liver Disease·Achintya D Singh, Shalimar
Feb 5, 2021·European Journal of Clinical Investigation·Domenico AlvaroUNKNOWN PReBRiC (Procedure-Related Bleeding Risk in Cirrhosis) group
Jan 20, 2019·Gastroenterology·Norah A Terrault, Tarek I Hassanein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.