Aversion hot spots in the dopamine system.

Current Opinion in Neurobiology
J P H VerharenStephan Lammel

Abstract

Through the development of optogenetics and other viral vector-based technologies, our view of the dopamine system has substantially advanced over the last decade. In particular, progress has been made in the reclassification of dopamine neurons based on subtypes displaying specific projections, which are associated with different features at the anatomical, molecular and behavioral level. Together, these discoveries have raised the possibility that individual groups of dopamine cells make a unique contribution to the processing of reward and aversion. Here, we review recent studies that have identified non-canonical dopamine pathways that are excited in response to aversive stimuli, including dopamine projections to the ventromedial shell of the nucleus accumbens, prefrontal cortex, tail of the striatum, and amygdala.

Citations

Dec 9, 2020·Psychiatry Research·Khethelo R XuluSian M J Hemmings
Feb 11, 2021·Immunity·Michela Matteoli, Davide Pozzi
Mar 5, 2021·The European Journal of Neuroscience·Verónica Pastor, Jorge Horacio Medina
Mar 19, 2021·Frontiers in Synaptic Neuroscience·Ximena I Salinas-Hernández, Sevil Duvarci
Oct 15, 2020·Neurobiology of Learning and Memory·Andrew R Tapper, Susanna Molas
Mar 12, 2021·Journal of Neurochemistry·Patrick T PiantadosiAndrew Holmes

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