Aversion or Salience Signaling by Ventral Tegmental Area Glutamate Neurons

IScience
David H RootMarisela Morales

Abstract

Ventral tegmental area (VTA) neurons play roles in reward and aversion. The VTA has, in addition to dopamine neurons, glutamatergic neurons expressing VGluT2. Here, by determining the firing patterns of VTA-VGluT2 neurons expressing channelrhodopsin 2, we identified a major subpopulation of VTA-VGluT2 neurons whose firing rates decreased or were unchanged during sucrose consumption and increased during facial airpuff presentation. We identified a small subpopulation of VTA-VGluT2 neurons whose firing rates increased in response to both rewarding and aversive stimuli. We also found that the changes in firing rate of some VTA-VGluT2 neurons were greater following reward delivery compared with reward omission, whereas others did not differ. We conclude that VTA-VGluT2 neurons are responsive to aversive stimuli, but subpopulations of VTA-VGluT2 neurons are differentially affected by sucrose reward. Reward-responsive subpopulations of VTA-VGluT2 neurons are also divided into those affected by reward expectation alone or the real-time delivery of reward.

Citations

Jul 21, 2020·Addiction Biology·Kaitlin C ReevesBrady K Atwood
Feb 6, 2020·Current Pharmaceutical Design·Kenneth D Carr
Sep 2, 2020·The Journal of Comparative Neurology·Maxime FougèreDimitri Ryczko
Mar 21, 2020·Nature Communications·Yuan HanJelena Radulovic
Dec 19, 2019·Frontiers in Cell and Developmental Biology·Sylvie Dumas, Åsa Wallén-Mackenzie
Feb 2, 2021·ACS Chemical Neuroscience·Thomas SteinkellnerDaniela Boassa
Jan 25, 2021·Journal of Neurochemistry·Yu Liu, Gavan P McNally
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Ryan D Shepard, Fereshteh S Nugent
Apr 19, 2020·Neuropharmacology·Joanna PerisEric G Krause
Jun 14, 2019·Neuroscience and Biobehavioral Reviews·Morgan M Rogers-Carter, John P Christianson
Jun 12, 2021·Nature Communications·Daniel C LowesAlexander Z Harris
May 23, 2020·Neuron·M Flavia BarbanoMarisela Morales

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Methods Mentioned

BETA
fluorescence microscopy

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