Avian and murine LR8B and human apolipoprotein E receptor 2: differentially spliced products from corresponding genes

Genomics
Christian BrandesJ Nimpf

Abstract

Apolipoprotein E-mediated lipid metabolism in the central nervous system plays an important role in cholesterol and phospholipid homeostasis of this organ, which is separated from the circulation by the blood-brain barrier. Moreover, in late-onset familial Alzheimer disease the frequency of the apolipoprotein E4 allele is significantly increased and the apoprotein is localized to extracellular plaques, one of the histological hallmarks of this disease. Recently, two distinct novel members of the low-density lipoprotein (LDL) receptor family, with the potential to bind apolipoprotein E and preferentially expressed in brain, have been characterized from human (D. Kim et al., 1996, J. Biol. Chem. 271: 8373-8380) and chicken and mouse (S. Novak, et al., 1996, J. Biol. Chem. 271: 11732-11736). The human receptor, termed "apolipoprotein E receptor 2," is a seven ligand-binding repeat receptor harboring a unique insertion in the cytoplasmic domain of the protein. The novel receptor characterized in chicken and mouse was found to have eight binding repeats without such a cytoplasmic insertion. Despite the overall identity of more than 73%, based upon their structural differences (seven versus eight ligand-binding repeats) these recepto...Continue Reading

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Citations

Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xia V YangJohn H Griffin
Sep 3, 1998·DNA and Cell Biology·T KanakiY Saito
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Oct 12, 2018·International Journal of Molecular Sciences·Paula Dlugosz, Johannes Nimpf
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Aug 28, 2020·Frontiers in Molecular Neuroscience·Christina M GalloUwe Beffert
Apr 28, 1999·Neuroscience·A E ClatworthyG W Rebeck
Apr 3, 2003·Brain Research. Molecular Brain Research·David BenhayonTom Curran

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