Abstract
Apolipoprotein E-mediated lipid metabolism in the central nervous system plays an important role in cholesterol and phospholipid homeostasis of this organ, which is separated from the circulation by the blood-brain barrier. Moreover, in late-onset familial Alzheimer disease the frequency of the apolipoprotein E4 allele is significantly increased and the apoprotein is localized to extracellular plaques, one of the histological hallmarks of this disease. Recently, two distinct novel members of the low-density lipoprotein (LDL) receptor family, with the potential to bind apolipoprotein E and preferentially expressed in brain, have been characterized from human (D. Kim et al., 1996, J. Biol. Chem. 271: 8373-8380) and chicken and mouse (S. Novak, et al., 1996, J. Biol. Chem. 271: 11732-11736). The human receptor, termed "apolipoprotein E receptor 2," is a seven ligand-binding repeat receptor harboring a unique insertion in the cytoplasmic domain of the protein. The novel receptor characterized in chicken and mouse was found to have eight binding repeats without such a cytoplasmic insertion. Despite the overall identity of more than 73%, based upon their structural differences (seven versus eight ligand-binding repeats) these recepto...Continue Reading
References
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S TakahashiT Yamamoto
May 9, 1989·Biochimica Et Biophysica Acta·W J Schneider
Apr 29, 1988·Science·R W Mahley
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N A ElshourbagyJ M Taylor
Aug 22, 1985·Biochimica Et Biophysica Acta·D HermierM J Chapman
Nov 1, 1984·Cell·T YamamotoD W Russell
Mar 24, 1995·The Journal of Biological Chemistry·L JacobsenJ Nimpf
Aug 4, 1995·The Journal of Biological Chemistry·T HiesbergerJ Nimpf
Nov 3, 1995·The Journal of Biological Chemistry·K M ArgravesD K Strickland
Sep 1, 1995·The Journal of Biological Chemistry·C W HeegaardP A Andreasen
Jun 30, 1995·The Journal of Biological Chemistry·S TakahashiT Nakai
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SaitoM G Farquhar
Apr 1, 1994·Current Opinion in Lipidology·K H WeisgraberW J Strittmatter
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Apr 5, 1996·The Journal of Biological Chemistry·D H KimT Yamamoto
May 17, 1996·The Journal of Biological Chemistry·S NovakJ Nimpf
Oct 4, 1996·The Journal of Biological Chemistry·H YamazakiY Saito
Citations
May 7, 1999·European Journal of Biochemistry·X M Sun, A K Soutar
Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xia V YangJohn H Griffin
Dec 2, 2009·The Journal of Biological Chemistry·Sarah DuitJohannes Nimpf
Sep 3, 1998·DNA and Cell Biology·T KanakiY Saito
Aug 10, 2002·The EMBO Journal·Walter StockingerJohannes Nimpf
Nov 12, 2002·The EMBO Journal·Stefanie KochJohannes Nimpf
Oct 23, 2009·Proceedings. Biological Sciences·Nicolas B Myant
Apr 15, 2004·Molecular and Cellular Biology·Peter MarschangJoachim Herz
Dec 16, 2005·Molecular and Cellular Biology·Harald MayerJohannes Nimpf
Aug 17, 1999·Annual Review of Nutrition·M M HussainA Bakillah
Oct 26, 2006·Molecular Neurodegeneration·G William RebeckEdwin J Weeber
Jul 11, 2007·Molecular Neurodegeneration·Rodrigo A FuentealbaMaria-Paz Marzolo
Nov 28, 2014·Science Signaling·Catherine R WasserJoachim Herz
Aug 17, 2005·Traffic·Loreto CuitinoMaría-Paz Marzolo
Aug 17, 2005·Neuron·Uwe BeffertJoachim Herz
Nov 26, 1999·Neuron·G D'ArcangeloT Curran
Jun 25, 1999·Cell·M TrommsdorffJ Herz
Mar 29, 2014·British Poultry Science·C WangD Q He
Nov 3, 2016·Frontiers in Cellular Neuroscience·Kazuhiro IshiiKazunori Nakajima
Nov 30, 2013·British Poultry Science·C WangY Z Gong
Nov 17, 2006·Biology of Reproduction·Tania FayadJacques G Lussier
Dec 21, 2000·Current Atherosclerosis Reports·W J SchneiderM Drexler
May 4, 2002·Nature Reviews. Genetics·Amitabh GuptaAnthony Wynshaw-Boris
May 23, 2012·International Journal of Oncology·Jürgen BeckerJörg Wilting
Apr 28, 2017·EMBO Reports·Hidenori HiraiTerukazu Nogi
Nov 21, 1998·The Journal of Biological Chemistry·W StockingerJ Nimpf
Oct 12, 2018·International Journal of Molecular Sciences·Paula Dlugosz, Johannes Nimpf
May 29, 2000·The Journal of Biological Chemistry·W StockingerJ Nimpf
Apr 11, 2001·The Journal of Biological Chemistry·C BrandesJ Nimpf
Dec 17, 2002·The Journal of Biological Chemistry·Guido HermeyJorgen Gliemann
Aug 28, 2020·Frontiers in Molecular Neuroscience·Christina M GalloUwe Beffert
Dec 23, 1998·Atherosclerosis·J Nimpf, W J Schneider
Apr 28, 1999·Neuroscience·A E ClatworthyG W Rebeck
Apr 3, 2003·Brain Research. Molecular Brain Research·David BenhayonTom Curran