Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis

Journal of Virology
Wayne TamPeter Besmer

Abstract

bic is a novel gene identified at a common retroviral integration site in avian leukosis virus-induced lymphomas and has been implicated as a collaborator with c-myc in B lymphomagenesis. It lacks an extensive open reading frame and is believed to function as an untranslated RNA (W. Tam, Gene 274:157-167, 2001; W. Tam, D. Ben-Yehuda, and W. S. Hayward, Mol. Cell. Biol. 17:1490-1502, 1997). The oncogenic potential of bic, particularly its ability to cooperate with c-myc in oncogenesis, was tested directly by expressing c-myc and bic, either singly or in pairwise combination, in cultured chicken embryo fibroblasts (CEFs) and in chickens using replication-competent retrovirus vectors. Coexpression of c-myc and bic in CEFs caused growth enhancement of cells. Most importantly, chick oncogenicity assays demonstrated that bic can cooperate with c-myc in lymphomagenesis and erythroleukemogenesis. The present study provides direct evidence for the involvement of untranslated RNAs in oncogenesis and provides further support for the role of noncoding RNAs as riboregulators.

References

Nov 17, 1978·Biochimica Et Biophysica Acta·T Graf, H Beug
Apr 3, 1992·Cell·G I EvanD C Hancock
Jan 1, 1990·Molecular and Cellular Biology·C I BrannanS M Tilghman
Feb 1, 1991·Molecular and Cellular Biology·S VerbeekA Berns
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P E NeimanG Loring
Jan 1, 1988·Annual Review of Immunology·S Cory, J M Adams
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T W Baba, E H Humphries
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M A RainesH J Kung
Sep 1, 1986·Molecular and Cellular Biology·R C SchwartzO N Witte
Jun 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·H Hanafusa
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Oct 21, 1993·Nature·Y HaoB Tycko
Jan 1, 1994·Advances in Immunology·P E Neiman
Oct 21, 1993·International Journal of Cancer. Journal International Du Cancer·Y HauptJ M Adams
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·B M Iritani, R N Eisenman
Oct 29, 2000·Cell·R L Kelley, M I Kuroda
Jan 11, 2000·Nucleic Acids Research·V A ErdmannJ Barciszewski
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·P E NeimanJ Delrow

❮ Previous
Next ❯

Citations

Nov 26, 2008·World Journal of Surgery·Min LiChangyi Chen
Aug 4, 2010·Archives of Virology·Benoît MuylkensDenis Rasschaert
Jul 9, 2010·International Journal of Hematology·Ai KotaniArinobu Tojo
Oct 18, 2003·Seminars in Cancer Biology·Michael T McManus
Sep 30, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Britta SkawranLudwig Wilkens
Sep 29, 2011·Nature Medicine·Suhwan ChangShyam K Sharan
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sukhinder K SandhuCarlo M Croce
Dec 1, 2007·The Journal of Biological Chemistry·Qinyan YinErik Flemington
Jun 30, 2011·Avian Pathology : Journal of the W.V.P.A·He-nan ZhangMing Liao
May 1, 2007·DNA and Cell Biology·Zhaojuan Yang, Ji Wu
May 17, 2007·DNA and Cell Biology·Sung-Liang YuJeremy J W Chen
Apr 15, 2006·Nucleic Acids Research·Kwan-Ho ChungDavid L Turner
Feb 28, 2008·The Cancer Journal·Muller FabbriGeorge A Calin
Aug 19, 2005·Science's STKE : Signal Transduction Knowledge Environment·John P Morris, Michael T McManus
Oct 24, 2008·Journal of Virology·Yuguang ZhaoVenugopal Nair
Oct 10, 2008·Journal of Virology·Robin MorganJoan Burnside
Sep 21, 2007·Journal of Virology·Rebecca L SkalskyRolf Renne
May 18, 2007·Annual Review of Genomics and Human Genetics·Tsung-Cheng Chang, Joshua T Mendell
Jul 28, 2009·Annual Review of Medicine·Ramiro GarzonCarlo M Croce
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marilena V Iorio, Carlo M Croce
Dec 28, 2011·The Keio Journal of Medicine·Tetsuro SetoyamaGeorge A Calin
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Elodie LagesJean-Paul Issartel
Aug 17, 2011·Journal of Nucleic Acids·Esmerina Tili, Jean-Jacques Michaille
Mar 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Peggy S EisJames E Dahlberg
Feb 27, 2015·Molecular and Cellular Therapies·Molly A Taylor, William P Schiemann
Sep 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giacoma De TullioAttilio Guarini
Jun 21, 2011·Biochimica Et Biophysica Acta·Robin W Morgan, Joan Burnside
Dec 15, 2015·The Journal of Clinical Investigation·Rinako NakagawaElena Vigorito
Jan 26, 2011·Drug Discovery Today·Jagat R KanwarRupinder K Kanwar
Feb 20, 2008·Seminars in Cancer Biology·Márta SzéllLajos Kemény
Feb 14, 2008·The Journal of Allergy and Clinical Immunology·Tara M LoveCarl D Novina
Aug 29, 2007·The American Journal of Pathology·Wenyong ZhangWayne Tam
May 29, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Erik A C Wiemer
Feb 21, 2009·Journal of Cellular and Molecular Medicine·Monika JungGlen Kristiansen
Dec 14, 2006·International Journal of Cancer. Journal International Du Cancer·Wei WuJianjun Chen
Jul 28, 2012·Chemical Biology & Drug Design·Palmiro PoltronieriOscar F D'Urso
May 22, 2010·European Journal of Clinical Investigation·Reuven Agami
Feb 12, 2010·Annals of the New York Academy of Sciences·Jan Davidson-MoncadaWayne Tam
Nov 4, 2004·Trends in Genetics : TIG·Peizhang XuBruce A Hay
Dec 20, 2005·Current Opinion in Genetics & Development·Scott M Hammond

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved