Avian bornavirus is present in many tissues of psittacine birds with histopathologic evidence of proventricular dilatation disease

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Raj RaghavDale A Smith

Abstract

Proventricular dilatation disease (PDD) is a neurologic disease of psittacine birds suspected to be caused by a recently identified Avian bornavirus (ABV). In the current report, data supporting the causal association of ABV with PDD are presented. Immunohistochemistry (IHC) with rabbit polyclonal antiserum raised against ABV nucleocapsid protein was used to identify cell and organ distribution of viral antigen. The ABV antigen was most consistently detected in brain, spinal cord, adrenal gland, pancreas, and kidney. Histopathologic evaluation was correlated with ABV-specific polymerase chain reaction (PCR) and immunohistochemical tests in multiple tissues from 16 psittacine birds with and without PDD. Using histopathologic diagnosis as the gold standard, the sensitivity and specificity of IHC for ABV antigens were found to be 100% and 100%, respectively. Many more tissues were positive for ABV RNA by reverse transcription PCR than were positive for pathologic changes or viral antigens by IHC, indicating the presence of subclinical or asymptomatic infection at many sites.

References

Jan 1, 1996·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·C R GregoryB W Ritchie
Feb 12, 1998·Australian Veterinary Journal·N D SullivanA Giles
Aug 22, 2000·The Journal of General Virology·P StaeheliM Schwemmle
Nov 9, 2002·The Journal of Infectious Diseases·Juan Carlos de la Torre
Dec 20, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·C H GrundJ Kösters
Jan 1, 2003·Research in Veterinary Science·S BreitW Künzel
Apr 6, 2006·Avian Pathology : Journal of the W.V.P.A·Richard E GoughDave Cavanagh
May 18, 2006·Emerging Infectious Diseases·Monika HilbeFelix Ehrensperger
Dec 20, 2007·Journal of Avian Medicine and Surgery·David PerpiñánAntoni Ramis
Mar 4, 2008·Journal of the American Veterinary Medical Association·Sophie E DennisonWilliam M Adams
Dec 3, 2008·Emerging Infectious Diseases·Kirsi S HonkavuoriW Ian Lipkin
Oct 1, 2001·Avian Pathology : Journal of the W.V.P.A·Y BerhaneB Hunter

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Citations

Dec 21, 2012·Animal Health Research Reviews·Susan L PayneDale A Smith
Dec 17, 2011·Emerging Infectious Diseases·Michael LierzDirk Enderlein
Apr 25, 2014·Avian Diseases·Rogério Venâncio DonattiNelson Rodrigo da Silva Martins
May 7, 2013·The Veterinary Clinics of North America. Exotic Animal Practice·Sharman M HoppesH L Shivaprasad
May 2, 2014·Journal of Wildlife Diseases·Pauline DelnatteDale A Smith
May 20, 2015·Avian Pathology : Journal of the W.V.P.A·Laura BourqueDale A Smith
Sep 13, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Arno WünschmannAníbal G Armien
Feb 13, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Pauline DelnatteDale A Smith
May 4, 2012·Journal of Feline Medicine and Surgery·Jonas J WensmanBodil S Holst
Aug 20, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Vanessa ZimmermannDennis Rubbenstroth
Feb 24, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Josephine M McHugh, Siwo R de Kloet
Mar 17, 2017·Avian Diseases·Julia HeckmannMichael Lierz
Jun 25, 2020·PloS One·Aila Solimar Gonçalves SilvaNelson Rodrigo da Silva Martins
Feb 6, 2017·Animal Health Research Reviews·Ian TizardSusan Payne
Jul 26, 2011·The Veterinary Record·Pauline DelnatteJosepha DeLay
Jan 21, 2020·Journal of Comparative Pathology·J Leal de AraujoR R Rech

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Datasets Mentioned

BETA
GQ496360

Methods Mentioned

BETA
biopsy
biopsies
column chromatography
size
gel filtration
light microscopy
PCR

Software Mentioned

ClustalW
SeqMan
Stata
MegAlign
Lasergene

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