Avian coccidiosis: changes in intestinal lymphocyte populations associated with the development of immunity to Eimeria maxima

Parasite Immunology
Lisa RothwellPete Kaiser

Abstract

The effect of infection and subsequent challenge with Eimeria maxima on the populations of lymphocytes in the small intestine of Light Sussex chickens was assessed by immunohistochemistry. T cells were characterized for CD3, CD4, CD8, TCR1 (gamma delta heterodimer) or TCR2 (alpha beta 1 heterodimer) markers, and B cells for the expression of IgM, IgA and IgG. After a primary inoculum there were, in both the epithelium and the lamina propria, two distinct increases in the numbers of T lymphocytes. The first peaked on days 3-5 and the second, greater influx, on day 11 after infection. CD4+ and CD8+ cells were represented in both peaks but, whereas CD4+ cells were found almost exclusively in the lamina propria, CD8+ cells were present in both sites. The area staining positive for CD8+ cells was somewhat greater than the value obtained for CD4+ cells. In the epithelium there was an early, small increase in TCR1(+)-staining, followed by a larger rise to the second peak, at which time there was also an increase in the lamina propria. Staining for TCR2+ cells followed the same pattern with a reversed distribution between epithelium and lamina propria. Changes after challenge were minimal and confined to the epithelium. The most notabl...Continue Reading

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Citations

Jan 13, 2010·Parasitology Research·Anke SühwoldAnja Taubert
Mar 17, 2011·Biological Trace Element Research·Yuanxin DengXiaodong Liu
Jan 25, 2012·Biological Trace Element Research·Yuanxin DengBangyuan Wu
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Mar 16, 2000·Developmental and Comparative Immunology·C H YunE P Lillehoj
Jun 16, 2009·Parasitology·V McDonald, M W Shirley
Aug 1, 2000·Avian Pathology : Journal of the W.V.P.A·L RothwellP Kaiser
May 20, 2008·Avian Pathology : Journal of the W.V.P.A·A B IdrisE A Krushinskie
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May 11, 2010·Trends in Parasitology·Michael Wallach
Mar 6, 2007·Veterinary Immunology and Immunopathology·W J C SwinkelsJ M J Rebel
Jan 17, 2007·Vaccine·Martin W ShirleyDamer P Blake
Jul 18, 2006·Parasite Immunology·D P BlakeA L Smith
Nov 11, 2005·Veterinary Immunology and Immunopathology·Willemien H WielandArjen Schots
Apr 2, 2002·Avian Diseases·Guangxing LiHyun S Lillehoj
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Feb 15, 2018·Infection and Immunity·Guangping HuangXianyong Liu
Dec 12, 2019·Frontiers in Immunology·Woo H KimHyun S Lillehoj

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