Avian eggshell thinning caused by transovarian exposure to o,p'-DDT: changes in histology and calcium-binding protein production in the oviduct uterus

The Journal of Toxicological Sciences
Ryo KamataKazuichi Nakamura

Abstract

Reproductive disorders in birds are the most characteristic effects of DDT contamination of wildlife. Experimental exposure of avian eggs to the estrogenic substance o,p'-DDT causes abnormal development of the reproductive tract (shortening of the left oviduct and aberrant development of the right oviduct) and eggshell thinning in mature birds, but it is still not known how eggshell thinning occurs in the abnormal oviduct. To fill this information gap, we examined the histology of the uterine part of the oviduct in Japanese quail treated in ovo with o,p'-DDT or a synthetic estrogen, diethylstilbestrol (DES), and we performed immunohistochemical staining for the calcium-binding proteins CALB1, SPP1, and TRPV6. Both o,p'-DDT-treated and DES-treated quail had few, and scattered, gland cells in the left uterus, unlike vehicle controls, in which gland cells tightly occupied the lamina propria. The aberrantly developed right uterus retained all the components of the normal left uterus, but in immature form. Immunostaining for CALB1, SPP1, and TRPV6 was greatly reduced by both o,p'-DDT and DES; SPP1 and TRPV6 immunostaining patterns, in particular, differed distinctly from those in the controls. These findings suggest that CALB1, SPP1...Continue Reading

References

Dec 1, 1995·Matrix Biology : Journal of the International Society for Matrix Biology·M PinesA Bar
Feb 19, 2003·Archives of Toxicology·Krister HalldinBjörn Brunström
Mar 5, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Monique van AbelRené J M Bindels
Apr 28, 2009·Environmental Toxicology and Chemistry·Ryo KamataHiroaki Shiraishi
May 1, 1970·Bulletin of Environmental Contamination and Toxicology·T G LamontW L Reichel

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