Avian influenza virus infection risk in humans with chronic diseases

Scientific Reports
Yaogang ZhongZheng Li

Abstract

Saliva proteins may protect older people from influenza, however, it is often noted that hospitalizations and deaths after an influenza infection mainly occur in the elderly population living with chronic diseases, such as diabetes and cancer. Our objective was to investigate the expression level of the terminal α2-3- and α2-6-linked sialic acids in human saliva from type 2 diabetes mellitus (T2DM), liver disease and gastric cancer (GC) patients and assess the binding activity of these linked sialic acids against influenza A viruses (IAV). We observed that the expression level of the terminal α2-3-linked sialic acids of elderly individuals with T2DM and liver disease were down-regulated significantly, and the terminal α2-6 linked sialic acids were up-regulated slightly or had no significant alteration. However, in the saliva of patients with GC, neither sialic acid was significantly altered. These findings may reveal that elderly individuals with chronic diseases, such as diabetes and liver disease, might be more susceptible to the avian influenza virus due to the decreased expression of terminal α2-3-linked sialic acids in their saliva.

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Citations

Dec 1, 2015·Biochemical and Biophysical Research Communications·Yaogang ZhongZheng Li
May 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sen WangXiong Guo
Nov 5, 2019·Epidemiology and Infection·Jiajun YangZheng Li
Jan 24, 2020·Expert Review of Proteomics·Hanjie YuZheng Li
Jan 9, 2019·Frontiers in Oncology·Liyuan JiaJihong Cui
May 12, 2018·Archives of Oral Biology·Juliana Ximenes DamascenoCristiane Sá Roriz Fonteles
May 1, 2021·Dentistry Journal·Akio Tada, Hidenobu Senpuku
Jul 30, 2019·Analytical Chemistry·Haoqi DuZheng Li

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