Avian paramyxovirus serotype-1: a review of disease distribution, clinical symptoms, and laboratory diagnostics.

Veterinary Medicine International
Nichole L Hines, Cathy L Miller

Abstract

Avian paramyxovirus serotype-1 (APMV-1) is capable of infecting a wide range of avian species leading to a broad range of clinical symptoms. Ease of transmission has allowed the virus to spread worldwide with varying degrees of virulence depending on the virus strain and host species. Classification systems have been designed to group isolates based on their genetic composition. The genetic composition of the fusion gene cleavage site plays an important role in virulence. Presence of multiple basic amino acids at the cleavage site allows enzymatic cleavage of the fusion protein enabling virulent viruses to spread systemically. Diagnostic tests, including virus isolation, real-time reverse-transcription PCR, and sequencing, are used to characterize the virus and identify virulent strains. Genetic diversity within APMV-1 demonstrates the need for continual monitoring for changes that may arise requiring modifications to the molecular assays to maintain their usefulness for diagnostic testing.

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Citations

Jan 22, 2013·Tropical Animal Health and Production·Kuttanda A NaveenKuldeep Dhama
Sep 4, 2012·Archives of Pharmacal Research·Howaida I Abd-AllaNagwa M M Shalaby
Mar 7, 2014·Avian Diseases·Luz Alba M G FornellsJosé Nelson S S Couceiro
May 26, 2016·Journal of Wildlife Diseases·Vincent ObandaSamer Angelone-Alasaad
Aug 5, 2017·Clinical and Experimental Vaccine Research·Kang-Seuk Choi
Sep 21, 2018·Veterinary Research·Zaib Ur RehmanMuhammad Munir
Sep 11, 2019·Tropical Animal Health and Production·Auleria A ApopoClaudio L Afonso
Mar 18, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Krysta H RogersBeate Crossley

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
electrophoresis
PCR
fluorescence resonance

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