Avirulant Salmonella typhimurium strains prevent food allergy in mice

Clinical and Experimental Immunology
P A EigenmannC P Frossard

Abstract

Oral tolerance to foods can be regulated by microorganisms in the gut lumen. We hypothesized that pretreatment with avirulent Salmonella typhimurium strains could prevent food allergy in mice. Mice were administered S. typhimurium PhoPc (STPhoPc) or S. typhimurium AroA prior to oral sensitization to beta-lactoglobulin in the presence of cholera toxin. An oral antigen challenge after sensitization assessed antigen-induced anaphylaxis. Antigen-specific antibody titres were measured by enzyme-linked immunosorbent assay in the serum and enzyme-linked immunospot (ELISPOT) in the spleen, and cytokine-secreting cells were measured by ELISPOT in the Peyer's patches, lamina propria and epithelium cells. We showed first that S. typhimurium could up-regulate interleukin (IL)-12 and IL-10 secretion by gut T cells. Mice pretreated with STPhoPc had decreased anaphylaxis upon challenge, along with decreased immumoglobulin G1 (IgG1) and IgE antibody titres. Mice having received S. typhimurium AroA had partly decreased anaphylaxis as well as decreased serum IgG1 antibody titres in the serum, and increased serum IgA antibody titres. Antibody titres could be correlated with increased numbers of spleen and Peyer's patches antibody-producing cells....Continue Reading

References

Feb 1, 1991·Microbial Pathogenesis·C E HormaecheB A Stocker
May 1, 1996·Archives of Disease in Childhood·D P StrachanR G Carpenter
Feb 9, 1999·The Journal of Allergy and Clinical Immunology·X M LiH A Sampson
Jul 11, 2000·The Journal of Allergy and Clinical Immunology·X M LiH A Sampson
Aug 25, 2001·Seminars in Respiratory Infections·S L Newman
Apr 20, 2002·Science·Maria YazdanbakhshRonald van Ree
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K ShidaS Kaminogawa
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed Elfatih H BashirCathryn Nagler-Anderson
Dec 5, 2002·The Journal of Allergy and Clinical Immunology·Suzanne S TeuberBob B Buchanan
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiu-Min LiHugh A Sampson
Nov 18, 2003·Allergy·P A Eigenmann
May 8, 2004·The Journal of Allergy and Clinical Immunology·Christophe P FrossardPhilippe A Eigenmann
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Christophe P FrossardPhilippe A Eigenmann
Feb 25, 2005·Allergy·D A Moneret-VautrinG Kanny
Apr 20, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K Adel-PatientJ-M Wal
Feb 24, 2007·The Journal of Allergy and Clinical Immunology·Christophe P FrossardPhilippe A Eigenmann

❮ Previous
Next ❯

Citations

Mar 1, 2011·The Journal of Allergy and Clinical Immunology·Richard T StraitFred D Finkelman
Oct 14, 2008·Current Opinion in Immunology·Justin M Skripak, Hugh A Sampson
Jan 22, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Philippe A Eigenmann
May 29, 2009·The Journal of Nutrition·Bastiaan SchoutenLéon M J Knippels

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.