Avoidable drug-gene conflicts and polypharmacy interactions in patients participating in a personalized medicine program

Personalized Medicine
Kristen K ReynoldsMark W Linder

Abstract

Determine the ability of a pharmacogenetic service, PRIMER, to identify drug-gene (DGI) and drug-drug interactions (DDI) in patients across multiple conditions. PRIMER consists of patient selection criteria, a gene panel and actionable guidance for DGIs and DDIs. The average patient was prescribed 12 medications. PRIMER identified significant DGIs in 73% of patients tested, with 43% having more than one DGI. DDIs were found in 87% of patients. The most common actionable DGIs were for opioid, psychotropic and cardiovascular medications. The pairing of patient selection criteria, a multigene panel with evidence-based interpretation and review of DDIs maximizes the patients tested who have actionable benefit and alerts physicians to potentially critical adjustments needed for the patient's medication regimen.

References

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Citations

Mar 28, 2019·Expert Review of Clinical Pharmacology·Ramón CacabelosJuan C Carril
Aug 24, 2018·Clinical Pharmacology and Therapeutics·Jason L VassyElaine C Alligood

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Methods Mentioned

BETA
genotyping

Software Mentioned

PGt
PRIMER

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