PMID: 6781009Jan 1, 1980

Avoidance behavior in rats selectively bred for differential alcohol sensitivity

Psychopharmacology
N R Shapiro, E P Riley

Abstract

"Most affected" (MA) and "least affected" (LA) rats, bred for extremes in motor impairment following an alcohol challenge, differed in their performance on two active avoidance tasks. In two-way shuttle avoidance, the MA line performed significantly better than the LA group, both in terms of response latencies and percent avoidances. The inferior performance of the LA line persisted across the 15 days of testing, and appeared to reflect an difference in asymptotic performance levels. In one-way avoidance, the MA line showed significantly better acquisition than the LA group; however, this difference dissipated across the 3 days of training. When tested following alcohol administration in either the one- or two-way avoidance paradigm, the MA rats showed a greater performance deficit than LA animals. These data were interpreted as indicating the generality of alcohol-related line differences to a situation motivated by aversive consequences. Moreover, the line difference in avoidance acquisition represents one of the few non-drug-related phenotypic differences that have been found in these lines. In previous generations, disparate base rates of wheel running have been reported, and the data presented here confirm and extend this ...Continue Reading

References

Sep 1, 1972·Physiology & Behavior·J K BelknapG E McClearn
Oct 1, 1973·Physiology & Behavior·A OliverioD W Bailey
Jul 1, 1973·Life Sciences·R P Camjanovich, J W MacInnes
Jun 1, 1972·Journal of Comparative and Physiological Psychology·A OliverioP Messeri
Oct 1, 1972·Behavioral Biology·P MesseriD Bovet

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