PMID: 6109035Jun 1, 1980Paper

Avoidance enhancement and discriminative response control by anxiolytics with drugs acting on the GABA system

Japanese Journal of Pharmacology
M OkaM Shimizu

Abstract

Two types of conditioned behaviors were investigated for the purpose of evaluating anxiolytic drugs. A conditioning procedure used was an active avoidance in poorly-performing mice. Chlordiazepoxide, diazepam, chlorazepate and meprobamate increased the avoidance rate, while chlorpromazine, haloperidol and nortriptyline did not produce such an effect. The effect of diazepam was potentiated by gamma-aminobutyric acid (GABA) and aminoxyacetic acid (AOAA) and antagonized by picrotoxin and thiosemicarbazide, but was influenced little by spiroperidol, alpha-methyltyrosine, phenoxybenzamine and levallorphan. In addition, the effect of other anxiolytics was potentiated by AOAA and antagonized by picrotoxin. Biperiden, methamphetamine, caffeine and morphine also induced an avoidance enhancement, which was not influenced by AOAA. A drug discrimination experiment was also performed using a milk-reinforced two-lever operant method. In the rats trained to discriminate phenobarbital from saline, diazepam produced a dose-related phenobarbital-lever selection, which was potentiated by AOAA and antagonized by picrotoxin. Chlordiazepoxide, chlorazepate and meprobamate also elicited responses on the phenobarbital-lever. On the other hand, haloper...Continue Reading

Citations

Jan 1, 1986·Psychopharmacology·I P StolermanI C Rose
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·J PodhornaR E Brown
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·E A MariathasanJ A White
Aug 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·G M RudenkoV M Chepelev
Jan 1, 1985·European Journal of Clinical Pharmacology·K P OhmanB E Karlberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here