Awaking Blood Pressure Surge and Progression to Microalbuminuria in Type 2 Normotensive Diabetic Patients

Journal of Diabetes Research
Michelangela BarbieriRaffaele Marfella

Abstract

We investigated the predictive value of morning blood pressure surge (MBPS) on the development of microalbuminuria in normotensive adults with a recent diagnosis of type 2 diabetes. Prospective assessments of 24-hour ambulatory blood pressure monitoring and urinary albumin excretion were performed in 377 adult patients. Multivariate-adjusted Cox regression models were used to assess hazard ratios (HRs) between baseline and changes over follow-up in MBPS and the risk of microalbuminuria. The MBPS was calculated as follows: mean systolic BP during the 2 hours after awakening minus mean systolic BP during the 1 hour that included the lowest sleep BP. After a mean follow-up of 6.5 years, microalbuminuria developed in 102 patients. An increase in MBPB during follow-up was associated with an increased risk of microalbuminuria. Compared to individuals in the lowest tertile (-0.67 ± 1.10 mmHg), the HR and 95% CI for microalbuminuria in those in the highest tertile of change (24.86 ± 6.92 mmHg) during follow-up were 17.41 (95% CI 6.26-48.42); p for trend <0.001. Mean SD MBPS significantly increased in those who developed microalbuminuria from a mean [SD] of 10.6 [1.4] to 36.8 [7.1], p < 0.001. An increase in MBPS is associated with the ...Continue Reading

References

Jul 15, 1994·American Journal of Epidemiology·M A CharlesW C Knowler
Oct 8, 1999·The New England Journal of Medicine·E Ritz, S R Orth
Apr 17, 2001·Hypertension·J R SowersE D Frohlich
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Sep 13, 2002·The New England Journal of Medicine·Empar LurbeDaniel Batlle
Jan 17, 2003·The New England Journal of Medicine·Daniel J BrotmanSabu Thomas
May 28, 2003·Journal of the American College of Cardiology·Roberto CeravoloFrancesco Perticone
Dec 13, 2006·Arquivos brasileiros de endocrinologia e metabologia·Daisy CrispimIsrael Roisenberg
Jun 15, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·S T KnudsenP L Poulsen
May 20, 2009·Annals of Internal Medicine·Rudy BilousHans-Henrik Parving
Jan 28, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Giacomo ZoppiniEnzo Bonora

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Citations

Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anberitha T Matthews, Matthew K Ross
Oct 27, 2018·Current Diabetes Reports·Vincenza Spallone

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