Awareness of hormesis will enhance future research in basic and applied neuroscience.

Critical Reviews in Toxicology
Mark P Mattson

Abstract

Hormesis is defined operationally as responses of cells or organisms to an exogenous or intrinsic factor (chemical, temperature, psychological challenge, etc.) in which the factor induces stimulatory or beneficial effects at low doses and inhibitory or adverse effects at high doses. The compendium of articles by Calabrese entitled "Neuroscience and Hormesis" provides a broad range of examples of neurobiological processes and responses to environmental factors that exhibit biphasic dose responses, the signature of hormesis. Nerve cell networks are the "first responders" to environmental challenges--they perceive the challenge and orchestrate coordinated adaptive responses that typically involve autonomic, neuroendocrine, and behavioral changes. In addition to direct adaptive responses of neurons to environmental stressors, cells subjected to a stressor produce and release molecules such as growth factors, cytokines, and hormones that alert adjacent and even distant cells to impending danger. The discoveries that some molecules (e.g., carbon monoxide and nitric oxide) and elements (e.g., selenium and iron) that are toxic at high doses play fundamental roles in cellular signaling or metabolism suggest that during evolution, organi...Continue Reading

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Citations

Nov 28, 2009·Neuromolecular Medicine·Sarah M Rothman, Mark P Mattson
Sep 10, 2009·Foodborne Pathogens and Disease·Marcos H Rostagno
Sep 16, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Paolo BellaviteAnita Conforti
Apr 13, 2011·Journal of Cell Communication and Signaling·Edward J Calabrese, Mark P Mattson
Mar 26, 2013·Neuroscience and Biobehavioral Reviews·Alessandra Berry, Francesca Cirulli
Dec 24, 2015·Pharmaceuticals·Dipita Bhakta-Guha, Thomas Efferth
Jan 10, 2012·Homeopathy : the Journal of the Faculty of Homeopathy·Marta MarzottoPaolo Bellavite
Aug 23, 2011·Environment International·Mélanie LemireDonna Mergler
Dec 17, 2008·Mechanisms of Ageing and Development·Tahira Farooqui, Akhlaq A Farooqui
May 19, 2009·BioFactors·Vittorio CalabreseEdward J Calabrese
Dec 24, 2009·Journal of Neurochemistry·Tae Gen SonMark P Mattson
Apr 12, 2015·Neurochemistry International·Vikneswaran Murugaiyah, Mark P Mattson
May 17, 2011·Neurotoxicology·Mélanie LemireDonna Mergler
Oct 19, 2010·Biochimica Et Biophysica Acta·Simonetta Camandola, Mark P Mattson
Sep 18, 2012·Frontiers in Neuroendocrinology·Staci D Bilbo, Jaclyn M Schwarz
Sep 1, 2009·Therapeutic Advances in Neurological Disorders·Albert C Ludolph, Sarah Jesse
Mar 6, 2018·Journal of Alzheimer's Disease : JAD·D Allan Butterfield
Apr 26, 2017·The EMBO Journal·Simonetta Camandola, Mark P Mattson
Sep 12, 2019·Cell Death & Disease·Arnaud TauffenbergerPierre J Magistretti
Jul 12, 2017·Scientific Reports·Hooman K MoghadamHelge Tveiten
Aug 25, 2018·Dose-response : a Publication of International Hormesis Society·Rehana K LeakMelvin E Andersen
Nov 20, 2016·Journal of Neuroscience Research·Manuela PennisiVittorio Calabrese
Apr 18, 2018·Frontiers in Medicine·Claudio FranceschiStefano Salvioli
Oct 19, 2016·Journal of Neuroscience Research·Vittorio CalabreseEdward J Calabrese
Jun 12, 2017·Environmental Science and Pollution Research International·Zewei CuiDongli Liang
Jan 1, 2017·Brain Circulation·Edward J CalabreseJames Giordano

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