Axial and cellular heterogeneity in electrolyte transport pathways along the thick ascending limb

Acta Physiologica
Henrik Dimke, J Schnermann

Abstract

The thick ascending limb (TAL) extends from the border of the inner medulla to the renal cortex, thus ascending through regions with wide differences in tissue solute and electrolyte concentrations. Structural and functional differences between TAL cells in the medulla (mTAL) and the cortex (cTAL) would therefore be useful to adapt TAL transport function to a changing external fluid composition. While mechanisms common to all TAL cells play a central role in the reclamation of about 25% of the NaCl filtered by the kidney, morphological features, Na+ / K+ -ATPase activity, NKCC2 splicing and phosphorylation do vary between segments and cells. The TAL contributes to K+ homeostasis and TAL cells with high or low basolateral K+ conductances have been identified which may be involved in K+ reabsorption and secretion respectively. Although transport rates for HCO3- do not differ between mTAL and cTAL, divergent axial and cellular expression of H+ transport proteins in TAL have been documented. The reabsorption of the divalent cations Ca2+ and Mg2+ is highest in cTAL and paralleled by differences in divalent cation permeability and the expression of select claudins. Morphologically, two cell types with different cell surface phenotype...Continue Reading

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Citations

Jul 28, 2019·Acta Physiologica·Nikolaus BerndtHermann-Georg Holzhütter
Dec 17, 2019·American Journal of Physiology. Renal Physiology·Lise BankirPascal Houillier
Jun 30, 2019·Journal of the American Society of Nephrology : JASN·Lihe ChenMark A Knepper
Mar 14, 2020·Genes·Caroline Prot-Bertoye, Pascal Houillier
Dec 8, 2020·American Journal of Physiology. Renal Physiology·Sebastian FrischeHenrik Dimke
Jun 22, 2021·American Journal of Physiology. Renal Physiology·Caroline Prot-BertoyeHenrik Dimke

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