Axial heterogeneity of sodium-bicarbonate cotransporter expression in the rabbit proximal tubule

The American Journal of Physiology
N AbuladzeI Kurtz

Abstract

It is generally accepted that Na(HCO3)n cotransport is the most important mechanism mediating basolateral bicarbonate efflux in the early proximal tubule. The presence of basolateral Na(HCO3)n cotransport in the late proximal tubule (S3 segment) and in the juxtamedullary S1 and S2 segments has been controversial. The renal sodium-bicarbonate cotransporter (NBC) has been recently cloned from rat (M. F. Romero, M. A. Hediger, E. L. Boulpaep, and W. F. Boron. J. Am. Soc. Nephrol. 7: 1259, 1996), salamander (M. F. Romero, M. A. Hediger, E. L. Boulpaep, and W. F. Boron. Nature 387: 409-413, 1997), and human (C. E. Burnham, H. Amlal, Z. Wang, G. E. Shull, and M. Soleimani. J. Biol. Chem. 272: 19111-19114, 1997). The localization of NBC in the kidney is unknown. The present study was designed to localize NBC mRNA expression in the rabbit proximal tubule. In situ hybridization studies were combined with functional studies of basolateral Na(HCO3)n cotransport in superficial and juxtamedullary S1, S2, and S3 segments of the rabbit proximal tubule. The results demonstrate that NBC mRNA is localized predominantly to the cortex, with less expression in the outer medulla. NBC expression was not detected in the inner medulla. The highest leve...Continue Reading

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Citations

Feb 9, 2000·American Journal of Physiology. Renal Physiology·T H KwonI Kurtz
Jan 15, 2002·American Journal of Physiology. Renal Physiology·Tae-Hwan KwonSøren Nielsen
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Eitan Gross, Ira Kurtz
Aug 29, 2003·American Journal of Physiology. Renal Physiology·Young-Hee KimSøren Nielsen
May 21, 2004·American Journal of Physiology. Cell Physiology·Natalia AbuladzeIra Kurtz
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Jie XuManoocher Soleimani
Apr 17, 2013·Physiological Reviews·Mark D Parker, Walter F Boron
Apr 11, 2018·American Journal of Physiology. Renal Physiology·Lijuan FangI David Weiner
Nov 22, 2002·American Journal of Physiology. Cell Physiology·Alexander PushkinIra Kurtz
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Pejvak SassaniIra Kurtz
Sep 1, 2000·American Journal of Physiology. Renal Physiology·H AmlalM Soleimani
Jun 13, 2019·American Journal of Physiology. Renal Physiology·Gunars OsisI David Weiner
Oct 29, 2000·American Journal of Physiology. Renal Physiology·H VorumC Aalkjaer

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