Axial stem cells deriving both posterior neural and mesodermal tissues during gastrulation

Current Opinion in Genetics & Development
Hisato Kondoh, Tatsuya Takemoto

Abstract

The posterior neural plate is primarily derived from the axial stem cells bipotential for neural and paraxial mesodermal development, which reside in the caudal lateral epiblast (CLE) of gastrulating amniote embryos. This process has been demonstrated only recently through cell lineage analyses and determination of Sox2 activation mechanisms. The alternative developmental pathways depend on the activation of either transcription factor genes Sox2 (neural) or Tbx6 (mesodermal); the latter occurs in association with cell ingression through the primitive streak. Tbx6 mutant embryos develop ectopic neural tubes at the expense of the paraxial mesoderm, as Sox2 is expressed even after cell ingression. While producing alternative somatic cell populations, the axial stem cells proliferatively maintain themselves through a process dependent on the Brachyury-Wnt3a coregulatory loop, and even contribute to a fraction of later stem cells of the tail bud in the chordoneural hinge (CNH). Experimental evidence for the above processes is discussed, and unsolved problems indicated.

References

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Citations

Jul 3, 2013·Annual Review of Cell and Developmental Biology·Bertrand Bénazéraf, Olivier Pourquié
Aug 6, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Roel NeijtsJacqueline Deschamps
Apr 1, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Tatsuya TakemotoHisato Kondoh
Mar 31, 2016·Journal of Anatomy·Michael D CearnsAndrew J Copp
Jul 16, 2014·Mechanisms of Development·Benedikt SchwartzPhillip Grote
Feb 27, 2015·ELife·Nicolas DenansOlivier Pourquié
Jun 10, 2016·Development, Growth & Differentiation·Hisato KondohTatsuya Takemoto
Apr 22, 2016·Molecular Biology of the Cell·Santiago O BouzasPablo H Strobl-Mazzulla
Jan 31, 2020·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hideaki IidaHisato Kondoh
Jul 6, 2019·Development·Norbert B Ghyselinck, Gregg Duester
Jan 2, 2019·International Journal of Molecular Sciences·Kah-Loon WongTakaaki Matsui
Apr 21, 2021·Developmental Cell·Elena Gonzalez-GobarttElisa Martí
Jul 8, 2021·Journal of Morphology·Julia GladyshevaVladimir Efremov
Aug 1, 2021·Development, Growth & Differentiation·Tatsuya YuikawaKyo Yamasu

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