Axillary dissection versus no axillary dissection in elderly patients with breast cancer and no palpable axillary nodes: results after 15 years of follow-up.

Annals of Surgical Oncology
Gabriele MartelliRoberto Agresti

Abstract

To assess the long-term safety of no axillary clearance in elderly patients with breast cancer and nonpalpable axillary nodes. Lymph node evaluation in elderly patients with early breast cancer and clinically negative axillary nodes is controversial. Our randomized trial with 5-year follow-up showed no breast cancer mortality advantage for axillary clearance compared with observation in older patients with T1N0 disease. We further investigated axillary treatment in a retrospective analysis of 671 consecutive patients, aged ≥ 70 years, with operable breast cancer and a clinically clear axilla, treated between 1987 and 1992; 172 received and 499 did not receive axillary dissection; 20 mg/day tamoxifen was prescribed for at least 2 years. We used multivariable analysis to take account of the lack of randomization. After median follow-up of 15 years (interquartile range 14-17 years) there was no significant difference in breast cancer mortality between the axillary and no axillary clearance groups. Crude cumulative 15-year incidence of axillary disease in the no axillary dissection group was low: 5.8% overall and 3.7% for pT1 patients. Elderly patients with early breast cancer and clinically negative nodes did not benefit in terms ...Continue Reading

References

Sep 1, 1994·Annals of Surgery·A E GiulianoD L Morton
Jul 1, 1996·International Journal of Radiation Oncology, Biology, Physics·B FowbleL J Goldstein
Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U VeronesiR Zucali
Feb 5, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I S FentimanUNKNOWN EORTC
Feb 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MustacchiUNKNOWN Italian Cooperative Group GRETA
Apr 16, 2004·Breast Cancer Research : BCR·Grazia ArpinoRichard M Elledge
Sep 3, 2004·The New England Journal of Medicine·Kevin S HughesUNKNOWN Eastern Cooperative Oncology Group
Jan 26, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U VeronesiP Maisonneuve
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Sep 15, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanUNKNOWN American Society of Clinical Oncology
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Breast Cancer Study GroupAlan S Coates
Dec 27, 2005·Current Opinion in Genetics & Development·Mei Zhang, Jeffrey M Rosen
Jan 27, 2006·The Cochrane Database of Systematic Reviews·D HindM W Reed
Mar 28, 2006·Cell·Michael F Clarke, Margaret Fuller
Jun 29, 2007·Annals of Surgical Oncology·James E GervasoniBlake Cady

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Citations

Apr 29, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G MartelliR Agresti
Nov 29, 2011·Breast Cancer Research and Treatment·M KiderlenG J Liefers
Oct 3, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M LuqueY Fernández
Oct 4, 2011·The Oncologist·Alice Ho, Monica Morrow
Dec 7, 2013·BMC Surgery·Alessandro CappellaniMassimiliano Berretta
Apr 28, 2011·Breast Cancer Research and Treatment·Bernd GerberToralf Reimer
Feb 26, 2013·AJR. American Journal of Roentgenology·Belinda LeeJustin Stebbing
Jul 1, 2011·Annals of Surgical Oncology·Monica Morrow, Armando E Giuliano
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Birgitte Vrou OffersenJens Overgaard
Aug 27, 2014·International Journal of Surgery·Alfonso ReginelliSalvatore Cappabianca
Dec 15, 2015·The British Journal of Surgery·M AhmedM Douek
Sep 8, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C NgôS Alran
Jan 13, 2012·Surgical Oncology·Desiree D D'Angelo-DonovanNicholas J Petrelli
Feb 14, 2012·Clinics in Geriatric Medicine·Andrew P ZbarRiccardo A Audisio
Oct 22, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M Barry, M R Kell
Jan 1, 2016·Critical Reviews in Oncology/hematology·Jacques BernierJean-Claude Horiot
Oct 14, 2014·The British Journal of Surgery·M MoossdorffM L Smidt
Apr 28, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R L O'ConnellG Q Della Rovere
Apr 22, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mandy KiderlenUNKNOWN eusomaDB Working Group
Jan 25, 2014·The Breast : Official Journal of the European Society of Mastology·J H VoldersW K De Roos
Mar 3, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F A AngaritaJ Escallon
Dec 1, 2012·Breast Care·Vikram SwaminathanRiccardo A Audisio
Jan 8, 2020·The Breast Journal·Jinny GunnEmmanuel Gabriel
Jun 27, 2019·Current Oncology Reports·Julia FrebaultAmanda L Kong
Jun 24, 2018·Irish Journal of Medical Science·Chwanrow Karim BabanJames Geraghty
Jul 16, 2020·Annals of Surgical Oncology·James SunMarie Catherine Lee
Apr 6, 2013·The International Journal of Biological Markers·Rosella SilvestriniMaria Grazia Daidone
Oct 6, 2012·Cancer Control : Journal of the Moffitt Cancer Center·Miraj Shah-Khan, Judy C Boughey
Feb 26, 2019·Breast Care·Carlos Martin LozaRcm Database Contributors
Jul 3, 2020·Annals of Surgical Oncology·James SunM Catherine Lee
Jan 12, 2019·BMC Cancer·Gilles HouvenaeghelJean Marie Boher

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Methods Mentioned

BETA
dissection
biopsy
X-ray

Software Mentioned

R
SAS

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