PMID: 9551330Apr 29, 1998Paper

Axillary hyperhidrosis: successful treatment with botulinum toxin A

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
M HeckmannG Plewig

Abstract

Severe hyperhidrosis may present as a vexing condition for the patient and a therapeutic challenge for the physician. As botulinum toxin-A (BT-A) can potently block cholinergic sympathic innervation of sweat glands it was used in an open trial for controlling severe axillary hyperhidrosis. After visualization of hyperhidrosis using the iodine-starch-test BT-A (Dysport, 400 Units) was injected intradermally in one axilla. One week later gravimetric quantification of sweat secretion revealed a reduction of sweating to 4-9% of initial values. In order to rule out daily variations as well as other factors interfering with sweat production BT-A treatment was restricted to only one axilla in each individual clearly demonstrating extensive anhidrotic efficacy on the treated side only. The treatment was well tolerated without side-effects and was assessed as 'completely satisfying' by all patients. BT-A may offer a fast, safe and highly effective therapeutic option for severe hyperhidrosis.

Citations

Jul 28, 2001·Seminars in Cutaneous Medicine and Surgery·R G Glogau
Oct 31, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·R Rompel, S Scholz
Feb 15, 2001·The New England Journal of Medicine·M HeckmannUNKNOWN Hyperhidrosis Study Group
Dec 23, 2017·Health Technology Assessment : HTA·Ros WadeNerys Woolacott
Mar 22, 2002·Journal of the American Academy of Dermatology·Uwe WollinaHelga Konrad

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