Axillary lymph node involvement in hormone-independent breast carcinomas

Medicina clínica
Alvaro Ruibal, José Ignacio Arias

Abstract

We decided to study the axillary lymph node invasion (N) in hormone-independent breast cancer. The study group included 77 ER and 47 ER/PgR breast carcinomas. Both ER and PgR were determined using EIAS from Abbott (USA). In ER tumors, one the most important finding was the high concentration (p = 0.001) and percentage of positives ( > 50 pmol/mg prot.; 24/41 vs 7/36; p < 0.01) of cathepsin D observed in N+ vs N- tumors. In ER/PgR negative tumors, lymph node involvement was associated with a same behavior of this proteinase (p = 0.021; 17/31 vs 2/16; p = 0.006) exclusively. Our results point to a possible usefulness of cathepsin D in this type of carcinomas.

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