Axis II Personality Disorders Are Linked to an Adverse Course of Bipolar Disorder

The Journal of Nervous and Mental Disease
Robert M PostMichael Rowe

Abstract

The relationship of personality disorder (PD) psychopathology to the course of bipolar disorder remains inadequately described. After giving informed consent, more than 782 outpatients with bipolar disorder rated themselves on the 99-item Personality Disorder Questionnaire, Version 4 (PDQ4) when depressed or euthymic. They also rated six poor prognosis factors (PPFs). The relationships of the PPFs to the total PDQ4 score were examined by a linear regression. Even after correcting for the higher PDQ4 scores observed when patients were suffering depression, the PDQ4 was significantly related to a history of child abuse, early age of onset, an anxiety disorder comorbidity, rapid cycling, and 20 or more previous episodes, but not substance abuse. The data suggest close relationships between the total burden of PD psychopathology and correlates of an adverse outcome of bipolar disorder. The nature of this of association and approaches to treatment of comorbid PD remain to be further explored.

References

May 1, 1990·Journal of the American Academy of Child and Adolescent Psychiatry·S P KutcherM Korenblum
Jun 1, 1990·Archives of General Psychiatry·M Zimmerman, W H Coryell
Jul 1, 1983·Archives of General Psychiatry·H S AkiskalB I Yerevanian
Aug 18, 1995·Journal of Affective Disorders·D CarpenterP J Wilner
May 1, 1996·Psychological Medicine·A J RushM H Trivedi
Jul 14, 2001·The British Journal of Psychiatry. Supplement·R M PostJ Walden
Apr 18, 2002·Biological Psychiatry·Gabriele S LeverichRobert M Post
May 21, 2003·The Journal of Clinical Psychiatry·Gabriele S LeverichRobert M Post
Oct 4, 2003·Bipolar Disorders·Robert M PostJorg Walden
May 4, 2006·The Journal of Clinical Psychiatry·Outi MantereErkki T Isometsä
Jun 4, 2008·Archives of General Psychiatry·Thomas N CrawfordStephanie Kasen
Jul 30, 2010·The Journal of Clinical Psychiatry·Robert M PostWillem A Nolen
Oct 7, 2010·The Journal of Clinical Psychiatry·Robert M PostWillem A Nolen
Dec 15, 2010·Journal of Psychiatric Research·Tracie O AfifiJitender Sareen
Dec 28, 2011·Pediatrics·Jack P ShonkoffUNKNOWN Section on Developmental and Behavioral Pediatrics
Apr 24, 2014·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tracie O AfifiJitender Sareen

❮ Previous
Next ❯

Citations

May 21, 2019·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Robert M Post
Jul 23, 2020·Journal of Affective Disorders·Robert M PostMichael Rowe
Mar 7, 2021·Medicina·Elvira Anna CarbonePasquale De Fazio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
J H KayJ Mintz
Expert Opinion on Pharmacotherapy
S Watson, A H Young
Journal of the American Academy of Child and Adolescent Psychiatry
S P KutcherM Korenblum
© 2022 Meta ULC. All rights reserved