Axis of ageing: telomeres, p53 and mitochondria.

Nature Reviews. Molecular Cell Biology
Ergün Sahin, Ronald A DePinho

Abstract

Progressive DNA damage and mitochondrial decline are both considered to be prime instigators of natural ageing. Traditionally, these two pathways have been viewed largely in isolation. However, recent studies have revealed a molecular circuit that directly links DNA damage to compromised mitochondrial biogenesis and function via p53. This axis of ageing may account for both organ decline and disease development associated with advanced age and could illuminate a path for the development of relevant therapeutics.

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R C AllsoppC B Harley
Mar 1, 1991·Mutation Research·C B Harley
May 31, 1990·Nature·C B HarleyC W Greider
Aug 30, 1990·Nature·N D HastieR C Allshire
Dec 2, 1993·Nature·C KenyonR Tabtiang
Apr 25, 2000·Experimental Cell Research·H AikataT Ide
Sep 27, 2001·Cell·E H Blackburn
Oct 24, 2001·Cell·H VaziriR A Weinberg
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shivani NautiyalElizabeth H Blackburn
Jul 13, 2002·Trends in Biochemical Sciences·Thomas von Zglinicki
May 20, 2003·Nature·Pere PuigserverBruce M Spiegelman
Sep 6, 2003·Current Biology : CB·Hiroyuki TakaiTitia de Lange
Dec 1, 1961·Experimental Cell Research·L HAYFLICK, P S MOORHEAD
Dec 5, 2003·Seminars in Pediatric Neurology·Susan PerlmanRichard A Gatti
Jan 15, 2004·The Journal of Clinical Investigation·Norman E Sharpless, Ronald A DePinho
Apr 7, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simon R W L Chan, Elizabeth H Blackburn
May 28, 2004·Nature·Aleksandra TrifunovicNils-Göran Larsson
Jul 6, 2004·Nature Genetics·Sandy ChangRonald A DePinho
Sep 16, 2004·Molecular and Cellular Biology·Xiaobing DuF Brad Johnson
Dec 1, 2004·Aging Cell·Janine Hertzog SantosBennett Van Houten
Dec 22, 2004·Mechanisms of Ageing and Development·Jae Wan LeeVilhelm A Bohr
Mar 1, 2005·Cell·David B LombardFrederick W Alt
May 4, 2005·Molecular Cell·Russell G JonesCraig B Thompson
Jul 23, 2005·Science·Ignacio FloresMaría A Blasco
Sep 2, 2005·Nature Reviews. Genetics·Maria A Blasco
Nov 16, 2005·Nature Medicine·Anna A SablinaPeter M Chumakov
Jan 5, 2006·Genes & Development·Susan M MendrysaMary Ellen Perry
Jan 26, 2006·Cell Cycle·William M Keyes, Alea A Mills

❮ Previous
Next ❯

Citations

Jul 24, 2013·Trends in Genetics : TIG·Bruno Bernardes de Jesus, Maria A Blasco
Sep 19, 2012·Genes & Development·Alessandro RufiniTak Wah Mak
Oct 1, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ke JinJingfeng Zhao
Jan 23, 2013·EMBO Molecular Medicine·Stefanie Dimmeler, Pierluigi Nicotera
Mar 12, 2013·Antioxidants & Redox Signaling·Meghan M Delmastro-GreenwoodJon D Piganelli
Oct 10, 2014·BioMed Research International·Shih-Yi ChuangJia-You Fang
Jun 10, 2014·Ageing Research Reviews·Antero SalminenKai Kaarniranta
Jun 14, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antero SalminenAnu Kauppinen
Sep 25, 2014·Respiratory Research·Matthew S WaltersRonald G Crystal
Aug 31, 2012·Science China. Life Sciences·Qian LiQingHua Shi
Dec 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kathryn K RidoutAudrey R Tyrka
Dec 9, 2015·Annual Review of Biomedical Engineering·Jude M PhillipDenis Wirtz
Jul 18, 2014·Neuron·Ram MadabhushiLi-Huei Tsai
Mar 19, 2013·Aging Cell·Miron ProkocimerYosef Gruenbaum
Mar 19, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·Justin TackneyKristen Hawkes
Mar 22, 2016·International Journal of Molecular Sciences·Benedetta Donati, Luca Valenti
Aug 22, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Josine E VerhoevenBrenda W J H Penninx
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Oct 16, 2015·Scientific Reports·Thibault BourgeronMaria Teresa Teixeira
May 23, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marta Gonzalez-FreireLuigi Ferrucci
May 8, 2015·Cell Cycle·Varvara PetrovaIvano Amelio
Feb 11, 2014·American Journal of Human Genetics·Hemanth TummalaInderjeet Dokal
Nov 29, 2014·Psychiatry and Clinical Neurosciences·Lakshmi Narayanan KotaSanjeev Jain
Nov 18, 2014·Aging Cell·Dorian V ZieglerMichael C Velarde
Jul 8, 2014·Oxidative Medicine and Cellular Longevity·Antonio AyalaSandro Argüelles
Aug 11, 2015·Cell Death and Differentiation·K PalikarasN Tavernarakis
Jun 6, 2015·Cell Stem Cell·Peter D AdamsK Lenhard Rudolph
Aug 30, 2013·Journal of Pharmacological Sciences·Golmaryam SarlakPiyarat Govitrapong
Dec 19, 2012·Journal of Hepatology·Scott L Friedman
Nov 7, 2012·Current Opinion in Cell Biology·Catarina M Henriques, Miguel Godinho Ferreira
Sep 6, 2012·Current Opinion in Cell Biology·Anthony J Cesare, Jan Karlseder
Oct 23, 2012·Current Opinion in Cell Biology·Bruno Bernardes de Jesus, Maria A Blasco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.