PMID: 6163507Mar 16, 1981Paper

Axoglial junctions in the mouse mutant Shiverer

Brain Research
J Rosenbluth

Abstract

Analysis of Shiverer central nervous tissue by the freeze-fracture method shows that axoglial junctions of the type found normally in the paranodal region occur commonly despite the gross reduction in myelin. On a substructural level these junctions appear identical to those that form between paranodal oligodendroglial processes and axolemma. On a grosser level, however, they are bizarre in shape, arrangement and distribution. Isolated glial processes, or small sheaves of them, course among axons and form such junctions in an irregular patchy manner, usually without apparent relationship to paranodal regions. These aberrant junctions may be oriented transversely, obliquely or longitudinally with respect to the axonal axis. Axolemmal E face particle accumulations, which characterize normal nodes of Ranvier, are usually not found in the membrane adjacent to the aberrant junctional patches. Thus, axoglial junctional specializations of the paranodal type can form in this mutant in the absence of the myelin proteins that are deficient in Shiverer, and such junctions may appear in areas not related to other paranodal or nodal structures. The relevance of these findings to differentiation of the axolemma and to the neurological defect...Continue Reading

References

Apr 1, 1979·Neuroscience Letters·A PrivatN Baumann
Oct 1, 1979·Journal of Neurocytology·J Rosenbluth
Sep 26, 1973·Nature: New Biology·S R Levinson, J C Ellory
Oct 1, 1980·The Journal of Comparative Neurology·J Rosenbluth
Dec 1, 1980·The Journal of Comparative Neurology·J Rosenbluth

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Citations

Jul 19, 2002·Journal of Neuroscience Research·Chika SeiwaHiroaki Asou
Dec 1, 1982·Journal of Neurocytology·A Hirano, H M Dembitzer
Aug 1, 1987·Journal of Neurocytology·J Rosenbluth
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J Rosenbluth
Jan 1, 1990·Annals of the New York Academy of Sciences·J Rosenbluth
Mar 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·German P Garcia-FrescoManzoor A Bhat
May 16, 2000·The Journal of Physiology·M N Rasband, P Shrager
Nov 11, 2008·Journal of the Neurological Sciences·Hoi Pang LowWilliam J Schwartz
Jan 27, 2009·Journal of Neuroscience Research·Liliana PedrazaDavid Colman
Nov 1, 2008·The European Journal of Neuroscience·Yoshio BandoShigetaka Yoshida
Feb 14, 2013·Journal of Neuroscience Research·Elizabeth D ButtermoreManzoor A Bhat
Sep 11, 2016·Journal of Neuroscience Research·Peter Shrager, Margaret Youngman
Sep 18, 2020·Journal of Neurochemistry·Sercin KarahuseyinogluYasemin Gürsoy-Özdemir

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