Axon extension and retraction by leech neurons: severing early projections to peripheral targets prevents normal retraction of other projections.

Neuron
W Q Gao, E R Macagno

Abstract

During leech embryogenesis, interactions between homologous neurons in neighboring segments lead to the selective retraction of longitudinal axonal projections by midbody AP and AE neurons, which maintain lateral axonal projections to the periphery. Results of experiments reported here show that disconnecting the lateral projections from the periphery rescues the projections normally fated to retract. We propose that these neurons normally progress through two states during early development, one in which they are insensitive to interactions with their homologs (state A) and a second in which they are sensitive (state B). Establishment of lateral connections with their targets triggers the switch from state A to state B; cutting these projections puts neurons back to state A.

References

Jan 1, 1979·Annual Review of Biophysics and Bioengineering·E R MacagnoI Sobel
Jan 1, 1988·Journal of Neuroscience Research·D P McCobbS B Kater
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E R MacagnoR R Stewart
Nov 1, 1985·Science·S S EasterN C Spitzer
Feb 1, 1981·The Journal of Physiology·K J Muller, S A Scott
Sep 21, 1984·Science·W M CowanB B Stanfield
Sep 1, 1984·The Journal of Comparative Neurology·J W Gillon, B G Wallace
Jun 22, 1984·Science·R K Murphey, C A Lemere

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Citations

Jun 1, 1994·Journal of Neurobiology·K A French, W B Kristan
Dec 19, 2007·Developmental Neurobiology·Teresa Sandoval-Minero, Alfredo Varela-Echavarría
Jan 15, 1992·The Journal of Comparative Neurology·J L Denburg, R T Caldwell
Apr 1, 1990·Journal of Neurogenetics·P A Hardy
Sep 22, 1994·Proceedings. Biological Sciences·B K Modney, K J Muller
Aug 1, 1989·Journal of Neuroscience Research·A G Bulloch
Feb 11, 1998·Physiological Reviews·R M Fitzsimonds, M M Poo

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